Scientific news
CEA
Monday December 15 2008
Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet.
Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet.
Proc. Natl. Acad. Sci. USA, (2008) 105, 17447-17452.
CEA
Monday December 15 2008
Le transfert d’électron par sauts successifs le long d’un fil moléculaire de 15 Å composé de trois résidus tryptophane dans la photolyase de l’ADN se fait en 30 ps.
Des changements d’absorption anisotropiques ultra-rapides ont été exploités pour suivre le transfert d’électron entre des espèces (trois résidus tryptophane) qui sont chimiquement identique, mais se distinguent par leurs orientations dans la protéine.
Le transfert d’électron par sauts successifs le long d’un fil moléculaire de 15 Å composé de trois résidus tryptophane dans la photolyase de l’ADN se fait en 30 ps.
Des changements d’absorption anisotropiques ultra-rapides ont été exploités pour suivre le transfert d’électron entre des espèces (trois résidus tryptophane) qui sont chimiquement identique, mais se distinguent par leurs orientations dans la protéine.
J Am Chem Soc, (2008) 130, 14394-14395
CEA
Sunday December 14 2008
Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.
Une équipe du SB2SM, en collaboration avec le groupe de Ken Shirasu au Riken Plant Institute de Yokohama, vient de caractériser les détails moléculaires du complexe entre HSP90 et SGT1 en couplant des approches de RMN, de biochimie et de modélisation.
Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.
Une équipe du SB2SM, en collaboration avec le groupe de Ken Shirasu au Riken Plant Institute de Yokohama, vient de caractériser les détails moléculaires du complexe entre HSP90 et SGT1 en couplant des approches de RMN, de biochimie et de modélisation.
EMBO Rep (2008), 9(12):1209-1215
CEA
Sunday December 14 2008
Gel chromatography and analytical ultracentrifugation to determine the extent of detergent binding and aggregation, and Stokes radius of membrane proteins using sarcoplasmic reticulum Ca2+-ATPase as an example.
Gel chromatography and analytical ultracentrifugation to determine the extent of detergent binding and aggregation, and Stokes radius of membrane proteins using sarcoplasmic reticulum Ca2+-ATPase as an example.
Nature Protocols,(2008) 3, 1782-1795
CEA
Sunday December 14 2008
Photosynthetic electron flow affects H2O2 signaling by inactivation of catalase in Chlamydomonas reinhardtii.
Photosynthetic electron flow affects H2O2 signaling by inactivation of catalase in Chlamydomonas reinhardtii.
Planta (2008) 228 : 1055-1066.
CEA
Friday November 14 2008
Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe: INSIGHTS INTO ACTIVITY-BASED PROBE DEVELOPMENT AND CONFORMATIONAL VARIABILITY OF MATRIX METALLOPROTEINASES.
Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe: INSIGHTS INTO ACTIVITY-BASED PROBE DEVELOPMENT AND CONFORMATIONAL VARIABILITY OF MATRIX METALLOPROTEINASES.
J Biol Chem, (2008), 283, 31058-67.
CEA
Friday November 14 2008
A dynamic stochastic model for DNA replication initiation in early embryos.
A dynamic stochastic model for DNA replication initiation in early embryos.
PLoS ONE, (2008), 3, e2919.
CEA
Thursday November 13 2008
Sequestering agents for uranyl chelation: new calixarene ligands.
Sequestering agents for uranyl chelation: new calixarene ligands.
Tetrahedron, (2008), 64, 11319-11324.
CEA
Thursday November 13 2008
Immunoprevalence of the CD4(+) T-cell response to HIV Tat and Vpr proteins is provided by clustered and disperse epitopes, respectively.
Immunoprevalence of the CD4(+) T-cell response to HIV Tat and Vpr proteins is provided by clustered and disperse epitopes, respectively.
Eur J Immunol, (2008), 38, 2821-31.
CEA
Tuesday October 14 2008
Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and NMS-occupied states.
Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and NMS-occupied states.
Mol Pharmacol, (2008), 74 (6): 1554-1563.
CEA
Tuesday October 14 2008
Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
Embo J, (2008), 27, 2411-2421.
CEA
Monday September 15 2008
Mediator-dependent recruitment of TFIIH modules in preinitiation complex.
Mediator-dependent recruitment of TFIIH modules in preinitiation complex.
Mol Cell, (2008), 31, 337-346.
CEA
Monday September 15 2008
A photoactive carotenoid protein acting as light intensity sensor.
A photoactive carotenoid protein acting as light intensity sensor.
Proc Natl Acad Sci USA, (2008), 105, 12075-12080.
CEA
Friday September 12 2008
Comprehensive analysis of HLA-DR- and HLA-DP4-restricted CD4+ T cell response specific for the tumor-shared antigen survivin in healthy donors and cancer patients.
Comprehensive analysis of HLA-DR- and HLA-DP4-restricted CD4+ T cell response specific for the tumor-shared antigen survivin in healthy donors and cancer patients.
J Immunol, (2008), 181, 431-439.
CEA
Friday September 12 2008
Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.
Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.
J Mol Biol, (2008), 382, 510-24.
CEA
Monday July 21 2008
CrAsH-quantum dot nanohybrids for smart targeting of proteins.
CrAsH-quantum dot nanohybrids for smart targeting of proteins.
J Am Chem Soc, (2008), 130, 8596-8597.
CEA
Monday July 21 2008
Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription.
Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription.
Genes & Dev, (2008), 22, 1934-47.
CEA
Sunday July 20 2008
Supramolecular self-assembly of amphiphiles on carbon nanotubes: a versatile strategy for the construction of CNT/metal nanohybrids, application to electrocatalysis.
Supramolecular self-assembly of amphiphiles on carbon nanotubes: a versatile strategy for the construction of CNT/metal nanohybrids, application to electrocatalysis.
J Am Chem Soc, (2008), 130, 8110-8111.
CEA
Sunday July 20 2008
Mass spectrometry-based metabolomics: accelerating the characterization of discriminating signals by combining statistical correlations and ultrahigh resolution.
Mass spectrometry-based metabolomics: accelerating the characterization of discriminating signals by combining statistical correlations and ultrahigh resolution.
Anal Chem, (2008), 80, 4918-32.
CEA
Saturday July 19 2008
Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve.
Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve.
J Immunol, (2008), 180, 7193-202.
CEA
Friday June 20 2008
A colorimetric assay for steady-state analyses of iodo- and bromoperoxidase activities.
A colorimetric assay for steady-state analyses of iodo- and bromoperoxidase activities.
Anal Biochem (2008), 379, 60-65.
CEA
Friday June 20 2008
Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy.
Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy.
Vaccine (2008), 26, 2615-2626.
CEA
Thursday June 19 2008
Isotopic labelling of photosystem II in Thermosynechococcus elongatus.
Isotopic labelling of photosystem II in Thermosynechococcus elongatus.
Photosynth Res (2008), 98, 285-92.
CEA
Thursday June 19 2008
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.
PloS ONE (2008), 3, e2174.
CEA
Tuesday May 13 2008
In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells.
In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells.
Mol Cell Biol (2008), 28, 3672-85.
CEA
Tuesday May 13 2008
Coevolution at protein complex interfaces can be detected by the complementarity trace with important impact for predictive docking.
Coevolution at protein complex interfaces can be detected by the complementarity trace with important impact for predictive docking.
PNAS (2008), 105, 7708-13.
Monday May 12 2008
Biosynthetic Exchange of Bromide for Chloride and Strontium for Calcium in the Photosystem II Oxygen-evolving Enzymes.
Biosynthetic Exchange of Bromide for Chloride and Strontium for Calcium in the Photosystem II Oxygen-evolving Enzymes.
J Biol Chem (2008), 283, 13330-40.
CEA
Monday May 12 2008
Detection of Staphylococcus enterotoxin B using fluorescent immunoliposomes as label for immunochromatographic testing.
Detection of Staphylococcus enterotoxin B using fluorescent immunoliposomes as label for immunochromatographic testing.
Anal Biochem (2008), 377, 182-188.
CEA
Friday April 11 2008
Small-Molecule Inhibitors of Sodium Iodide Symporter Function.
Small-Molecule Inhibitors of Sodium Iodide Symporter Function.
ChembioChem (2008), 9, 889–895
CEA
Thursday April 10 2008
Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2.
Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2.
J Med Chem (2008), 51, 2216-2226
CEA
Wednesday April 09 2008
Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.
Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.
Hum Mol Genet (2008), 17, 1446-1456.
CEA
Tuesday March 11 2008
Cobaloxime-based photocatalytic devices for hydrogen production.
Cobaloxime-based photocatalytic devices for hydrogen production.
Angew Chem Int Ed Engl (2008), 47, 564-567.
CEA
Monday March 10 2008
Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription.
Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription.
Mol Cell Biol (2008), 28, 1596-1605.
CEA
Sunday March 09 2008
Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum.
Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum.
Anal Chem (2008), 80, 1737-1745
CEA
Friday February 15 2008
Inference and validation of Synechocystis protein interaction network using orthology.
Inference and validation of Synechocystis protein interaction network using orthology.
JOBIM (2007), 229-234.
CEA
Friday February 15 2008
Two [Fe(IV)=O Trp*] intermediates in M. tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid.
Two [Fe(IV)=O Trp*] intermediates in M. tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid.
J Am Chem Soc (2007), 129, 15954-15963.
Thursday February 14 2008
A reporter system for the individual detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo.
A reporter system for the individual detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo.
Plant J (2007), 50, 475-487.
CEA
Tuesday January 15 2008
Structural and Functional Analysis of SGT1 Reveals That Its Interaction with HSP90 Is Required for the Accumulation of Rx, an R Protein Involved in Plant Immunity.
Structural and Functional Analysis of SGT1 Reveals That Its Interaction with HSP90 Is Required for the Accumulation of Rx, an R Protein Involved in Plant Immunity.
Plant Cell (2007), 19, 3791-3804.
CEA
Tuesday January 15 2008
Crystal Structure of a Ternary Complex between Human Prostate-specific Antigen, Its Substrate Acyl Intermediate and an Activating Antibody.
Crystal Structure of a Ternary Complex between Human Prostate-specific Antigen, Its Substrate Acyl Intermediate and an Activating Antibody.
J Mol Biol (2008), 376, 1021-33.
CEA
Monday January 14 2008
Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury.
Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury.
Hepatology (2008), 47, 177-185.
CEA
Monday January 14 2008
Changements structuraux dans le complexe Mn4Ca du Photosystème II au cours du cycle enzymatique conduisant à l’oxydation de l’eau.
Changements structuraux dans le complexe Mn4Ca du Photosystème II au cours du cycle enzymatique conduisant à l’oxydation de l’eau.
PNAS (2008), 105, 1879-1884.