A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines.
A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated
tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.
Céline François-Endelmond, Thomas Carlin, Pierre Thuery, Olivier Loreau and Frédéric Taran.2010. A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines. Org. Lett., 12, 40-42.