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Monday 15 February 2010

A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines.

Org. Lett. 2010, 12, 40-42.
CEA


A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated

tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

Céline François-Endelmond, Thomas Carlin, Pierre Thuery, Olivier Loreau and Frédéric Taran.2010. A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines. Org. Lett., 12, 40-42.