Saturday February 14 2009
CEA
Sensitivity and Multiplexing Capabilities of MRI Based on Polarized (129)Xe Biosensors.
J Am Chem Soc. (2008) 130 16456-16457.
CEA
129Xe MRI is applied to cage molecules in which hyperpolarized xenon exhibits a specific spectral signature. In a few tens of seconds a net spatial discrimination is achieved between xenon in two different hosts dissolved in two immiscible media at submillimolar concentrations by using a gradient echo sequence with interleaved frequency selection. This high sensitivity is afforded not only by the hyperpolarized state of xenon but also by the continuous xenon in-out exchange that enables replenishment of the detected signal. Moreover in this direct approach, simultaneous detection of xenon in two different cage molecules is possible. This experiment on a model system is an important step toward in vivo multiplexed MRI using laser-polarized xenon.
Berthault P, Bogaert-Buchmann A, Desvaux H, Huber G, and Boulard Y (2008) Sensitivity and multiplexing capabilities of MRI based on polarized 129Xe biosensors. J Am Chem Soc. 130 16456-16457.
