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Scientific results

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cellules Natural Killer
Monday 30 September 2013
Cancer: a new key to explain the paralysis of the immune system

Cancerous cells that are invisible to the immune system? An international collaboration (France, Italy, China, Australia), directed by the ENS-Lyon and involving the CEA-IRCM, has revealed the double role of the TRF2 protein, as well as its association with another protein to participate in blocking the immune system’s ability to fight against the tumor.
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells | Nature Cell Biology, 2013
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Tuesday 02 April 2013
Producing new neurons under all circumstances: just a mouse away…

Improving neuron production in elderly persons presenting with a decline in cognition is a major challenge facing an ageing society and the emergence of neuro-degenerative conditions such as Alzheimer’s disease. INSERM and CEA researchers recently showed that the pharmacological blocking of the TGFβ molecule improves the production of new neurons in the mouse model. These results incentivise the development of targeted therapies enabling improved neuron production to alleviate cognitive decline in the elderly and reduce cerebral lesions caused by radiotherapy. The research is published in the journal EMBO Molecular Medicine.
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Friday 18 January 2013
Experimental proof for the harmful effects of bisphenol A

A team from the CEA-iRCM has just experimentally demonstrated for the first time that low concentrations of bisphenol A are sufficient to have a negative impact on human testes.
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