Version française

Scientific results

2013 - 2012 - 2011 - 2010 - 2007 - 2006 - 2005 - 2004 - 2003 - 2002
Friday 04 June 2004
A system that repairs DNA double strand breaks is responsible for genetic instability in mammals

Researchers at the laboratory for the study of genetic recombination mechanisms and the Department of radiobiology and radiopathology DRR) have identified the factor responsible for genetic instability after DNA double strand breaks (DSB) in mammals. It proves to be one of the two main DSB repair pathways, the NHEJ system, which works by joining up the broken DNA ends (end-joining). The researchers have shown not only that this repair pathway generates chromosomal rearrangements, mainly DNA loss, but also that it is the main pathway for the repair of DSB, which occur in particular after genotoxic stress such as ionising radiation.
Mol Cell. (2004) 14:611-623
En savoir plus
Tuesday 01 June 2004
The double life of protein p53

Researchers at the Laboratory for the study of genetic recombination mechanisms at the department of radiobilogy and radiopathology (DRR) have published a review on the double life of protein p53, which acts as the ?genome caretaker'. Its intervention, indirectly on the cell cycle and apoptosis, and directly on the DNA repair system, may constitute two complementary systems to safeguard the integrity of the genome.
Trends in Genet. (2004) 20:235-243
En savoir plus
Friday 30 January 2004
A method for the purification of germinal stem cells

Researchers at the germinal stem cell radiosensitivity laboratory (DRR) have just characterised a method for the concentration of germinal stem cells that offers an essential tool for the analysis of genetic and hereditary risks due to exposure to genotoxic agents.
Development (2004) 131 : 479? 487
En savoir plus
2013 - 2012 - 2011 - 2010 - 2007 - 2006 - 2005 - 2004 - 2003 - 2002