Scientific results
Wednesday 07 September 2005
The protein Rap1 protects genome integrity by preventing chromosomal fusions
A team at the Department of Radiobiology and Radiopathology (DRR, CEA Fontenay-aux-Roses) has identified a molecular pathway by which telomeres prevent the chromosome fusions that characterize tumours.
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The protein Rap1 protects genome integrity by preventing chromosomal fusions
A team at the Department of Radiobiology and Radiopathology (DRR, CEA Fontenay-aux-Roses) has identified a molecular pathway by which telomeres prevent the chromosome fusions that characterize tumours.
EMBO J., (2005) 24:3117-3127
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Saturday 03 September 2005
Des vecteurs spécifiques, efficaces et stables pour éteindre l'expression de gènes humains et créer de nouveaux modèles de maladie
A research team belonging to the Laboratory of Genetics of Radiosensitivity (DRR, CEA Fontenay-aux-Roses) has described a new stable system based on RNA interference that can mimic certain human diseases. The vectors constructed make it possible, for the first time, to silence selected genes for more than 300 days. Targeted on two specific proteins (XPA and XPC) of one of the major DNA repair systems (NER), this tool was used to devise a cell model of xeroderma pigmentosum, a disease characterised by a high frequency of cancer and a sensitivity to sunlight 1000 times higher than normal.
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Des vecteurs spécifiques, efficaces et stables pour éteindre l'expression de gènes humains et créer de nouveaux modèles de maladie
A research team belonging to the Laboratory of Genetics of Radiosensitivity (DRR, CEA Fontenay-aux-Roses) has described a new stable system based on RNA interference that can mimic certain human diseases. The vectors constructed make it possible, for the first time, to silence selected genes for more than 300 days. Targeted on two specific proteins (XPA and XPC) of one of the major DNA repair systems (NER), this tool was used to devise a cell model of xeroderma pigmentosum, a disease characterised by a high frequency of cancer and a sensitivity to sunlight 1000 times higher than normal.
Mol. Cancer Research, (2005) 3: 519-529
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Tuesday 30 August 2005
Potential efficacy of a new type of anticancer agent
A research team at the Department of Radiopathology (DRR ? CEA Fontenay-aux-Roses), in collaboration with Sanofi-Aventis, has demonstrated the efficacy in cell cultures of a new group of potential anticancer agents. These compounds preferentially bind structures at the end of chromosomes called telomeres, leading to multiple alterations of the cell cycle and death of cancer cells.
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Potential efficacy of a new type of anticancer agent
A research team at the Department of Radiopathology (DRR ? CEA Fontenay-aux-Roses), in collaboration with Sanofi-Aventis, has demonstrated the efficacy in cell cultures of a new group of potential anticancer agents. These compounds preferentially bind structures at the end of chromosomes called telomeres, leading to multiple alterations of the cell cycle and death of cancer cells.
Oncogene, (2005) 24: 2917-2928
NAR, (2005) 33: 4182-4190
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Thursday 30 June 2005
Characterisation of new markers of very low-dose exposure
A research team at the Functional Genomics Department (DRR/SGF) has succeeded in identifying potential markers of exposure to low doses. A DNA chip dedicated to low doses is being constructed.
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Characterisation of new markers of very low-dose exposure
A research team at the Functional Genomics Department (DRR/SGF) has succeeded in identifying potential markers of exposure to low doses. A DNA chip dedicated to low doses is being constructed.
Radiation Research (2005) 163 : 623-635
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Wednesday 25 May 2005
Genotoxic stress and control of DNA replication. Role of protein Kin17
Researchers at the Department of Genetics and Radiosensitivity (DRR/LGR) have shed new light on the probable role of a protein induced by ionising radiation, Kin17, in the mechanisms of regulation of DNA replication in cases of genotoxic stress.
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Genotoxic stress and control of DNA replication. Role of protein Kin17
Researchers at the Department of Genetics and Radiosensitivity (DRR/LGR) have shed new light on the probable role of a protein induced by ionising radiation, Kin17, in the mechanisms of regulation of DNA replication in cases of genotoxic stress.
Mol Cell Biol (2005) 25:3814-3830.
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Tuesday 08 February 2005
Discovery of a protein able to regulate the variability of a pathogenic bacterium
Jointly with the Pasteur Institute, a research team at the Department of Radiobiology and Radiopathology has demonstrated the essential role played by the process of DNA recombination in the adaptability of the bacterium Helicobacter pylori , responsible for ulcers, gastritis and stomach cancer. The discovery of a protein (MutS2) able to regulate recombination rate may offer a means to restrict the growth of this bacterium during infections or antibiotic treatments.
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Discovery of a protein able to regulate the variability of a pathogenic bacterium
Jointly with the Pasteur Institute, a research team at the Department of Radiobiology and Radiopathology has demonstrated the essential role played by the process of DNA recombination in the adaptability of the bacterium Helicobacter pylori , responsible for ulcers, gastritis and stomach cancer. The discovery of a protein (MutS2) able to regulate recombination rate may offer a means to restrict the growth of this bacterium during infections or antibiotic treatments.
Mol. Cell., (2005) 17: 113-120
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Tuesday 08 February 2005
The control of homologous recombination, a process conserved across species
Researchers in the DNA repair research unit at CEA Fontenay-aux-Roses, jointly with a team of the Gustave-Roussy Institute, Villejuif and the University of Paris V, have demonstrated that the mechanisms of homologous recombination control are conserved from bacteria to yeast (a model organism). This control works by removing from DNA certain elements that are necessary for the recombination process.
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The control of homologous recombination, a process conserved across species
Researchers in the DNA repair research unit at CEA Fontenay-aux-Roses, jointly with a team of the Gustave-Roussy Institute, Villejuif and the University of Paris V, have demonstrated that the mechanisms of homologous recombination control are conserved from bacteria to yeast (a model organism). This control works by removing from DNA certain elements that are necessary for the recombination process.
Embo J. (2005) 24: 180-189
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