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Institutes/ Institute of environmental biology and biotechnology (IBEB)/ Services iBEB/ Department of biochemistry and nuclear toxicology (SBTN)/ Research topics

Research topics


Biochemical approaches to the study of toxicological and radiobiological mechanisms; Environmental detection and biosafety diagnosis; Biotechnological applications of recombinant proteins.

A - Nuclear and radiobiology toxicology 

Toxicogenomics; Identification and characterization of molecular targets of toxic compounds, in particular metals (U, Co), in biological fluids and human cells.

Genetic screening for nuclear import-export effector molecules, in particular p53.

Structural bases of iodine transport and medical applications of NIS.
Structural units of protein complexes involved in human genome integrity checkpoint networks.

1 - Protein targets of uranyl cations (Claude Vidaud)
2 - Modeling of uranyl-protein interactions (Olivier Pible)
3 - Thioredoxin-cadmium interactions (Françoise Rollin-Genetet)
4 - Copper transport: Hah1 and Menkes proteins (Valérie Tanchou)
5 - Biochemical and structural characterization of sodium-iodine symporter (Élizabeth Darrouzet)

 
 

7 - Cellular response of cultured human cells to uranyl ions (Odette Prat)
8 - Biological response of human lung cells to cobalt (Véronique Malard)
9 - Functional analysis of human b-TrCp as part of ubiquitin/proteasome pathway (Valérie Tanchou)
10 - Nuclear relocation of transcription factors after genotoxic stress (Christian Godon)

 
B - Post-genomic biochemestry - Exploring new concepts in post-genomic biochemistry
 Based on genome computer analysis, identification of new orphan proteins of medical or toxicological interest. Recombinant protein production for structural and functional studies, identification of interactants and topological analysis based on biochemical methods

1 - PACEs: key proteins identified by comparative genomics (Jean Armengaud)
2 - Proteoluzerne: industrial proteomics of Medicago sativa (Anne Incamps)

     
C - Biosafety - Environmental toxins

Development of new detection methods for bacterial and algal toxins and live organisms

Recombinant antibodies for diagnostic and therapeutic use

1 - Monoclonal antibodies against botulinum toxins (Laurent Bellanger)
2 - Environmental detection of saxitoxins (Fabienne Gas)