2013
2013
CEA
Monday 29 April 2013
Flexible-meccano
Flexible-meccano: A tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
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Flexible-meccano
Flexible-meccano: A tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
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CEA
Friday 26 April 2013
Toward chemical inhibitors of angiogenesis
Screening a chemical library led to the identification of a family of molecules, whith one has been tested by researchers at the Laboratory of Cancer Biology and Infection for its anti-angiogenic and anti-tumor capabilities on mice in vivo tumorigenesis models.
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Toward chemical inhibitors of angiogenesis
Screening a chemical library led to the identification of a family of molecules, whith one has been tested by researchers at the Laboratory of Cancer Biology and Infection for its anti-angiogenic and anti-tumor capabilities on mice in vivo tumorigenesis models.
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CEA
Friday 26 April 2013
Sulphur in Biology
Only four proteins are described as being able to achieve radical direct insertion of a sulfur atom in a CH bond of biomolecules. The poorly understood mechanism behind such an insertion reflect at most one turnover in vitro. These systems are called "sacrificial" because the sulfur of the FeS centers of these proteins is the one which is found in the substrate. Thanks to this new publication, researchers from the Chemistry and biology of metals laboratory propose a mechanism allowind these enzyme systems to achieve more in vitro turnover.
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Sulphur in Biology
Only four proteins are described as being able to achieve radical direct insertion of a sulfur atom in a CH bond of biomolecules. The poorly understood mechanism behind such an insertion reflect at most one turnover in vitro. These systems are called "sacrificial" because the sulfur of the FeS centers of these proteins is the one which is found in the substrate. Thanks to this new publication, researchers from the Chemistry and biology of metals laboratory propose a mechanism allowind these enzyme systems to achieve more in vitro turnover.
En savoir plus
CEA
Friday 26 April 2013
Proteomic analysis of lysosomes
Lysosomes are intracellular organelles having a function of cell bin, and where the non-functional molecules are removed by digestion. To identify new proteins that may be involved in certain diseases related to these organelles, researchers from Large Scale Biology Laboratory performed a proteomic analysis of lysosomes.
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Proteomic analysis of lysosomes
Lysosomes are intracellular organelles having a function of cell bin, and where the non-functional molecules are removed by digestion. To identify new proteins that may be involved in certain diseases related to these organelles, researchers from Large Scale Biology Laboratory performed a proteomic analysis of lysosomes.
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CEA
Wednesday 27 February 2013
Biomimetic system
To understand the dynamics of the actin cytoskeleton, researchers at the Plant Cell & Physiology Laboratory and Institut Curie have developed an in vitro biomimetic system to reconstitute it. By coupling a model reflecting the complexity of this dynamic, it becomes possible to identify and formulate the principles governing the cytoskeletal dynamics and organization. This research allows for example to highlight the consequences of intracellular mechanical malfunctions for diseases such as cancer.
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Biomimetic system
To understand the dynamics of the actin cytoskeleton, researchers at the Plant Cell & Physiology Laboratory and Institut Curie have developed an in vitro biomimetic system to reconstitute it. By coupling a model reflecting the complexity of this dynamic, it becomes possible to identify and formulate the principles governing the cytoskeletal dynamics and organization. This research allows for example to highlight the consequences of intracellular mechanical malfunctions for diseases such as cancer.
En savoir plus
CEA
Wednesday 27 February 2013
Bacterial civil war
Researchers from the Cancer Biology and Infection Laboratory identified at the surface of Pseudomonas aeruginosa a new secretion system (SST6) allowing injection of toxins or other effectors. In this study, they show that accessories genes coding for SST6, are most likely involved in a signaling trans-membrane pathway promoting the development of the injection device under certain environmental conditions.
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Bacterial civil war
Researchers from the Cancer Biology and Infection Laboratory identified at the surface of Pseudomonas aeruginosa a new secretion system (SST6) allowing injection of toxins or other effectors. In this study, they show that accessories genes coding for SST6, are most likely involved in a signaling trans-membrane pathway promoting the development of the injection device under certain environmental conditions.
En savoir plus
CEA
Wednesday 27 February 2013
in vivo biofilms
The formation of bacterial biofilms may be the cause of nosocomial infections or antibiotic resistance. While most research on the mechanisms of formation of these biofilms is made in vitro, a collaboration of a team at the Large Scale Biology Laboratory and Dr. de Bentzmann, Université Aix-Marseille, has yielded in vivo results in the formation of biofilms of Pseudomonas aeruginosa in Drosophila. The foundation for further research can be launched.
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in vivo biofilms
The formation of bacterial biofilms may be the cause of nosocomial infections or antibiotic resistance. While most research on the mechanisms of formation of these biofilms is made in vitro, a collaboration of a team at the Large Scale Biology Laboratory and Dr. de Bentzmann, Université Aix-Marseille, has yielded in vivo results in the formation of biofilms of Pseudomonas aeruginosa in Drosophila. The foundation for further research can be launched.
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Piscine d'entreposage de combustibles nucléaires ©L.Godart/CEA
Tuesday 12 February 2013
The discovery of microalgae with an exceptional radiotolerance
A new, highly radiotolerant microalga species has just been isolated from a cooling pool for spent nuclear fuel. After analyzing the properties of this unique species, researchers now foresee new strategies for bioremediation [1].
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The discovery of microalgae with an exceptional radiotolerance
A new, highly radiotolerant microalga species has just been isolated from a cooling pool for spent nuclear fuel. After analyzing the properties of this unique species, researchers now foresee new strategies for bioremediation [1].
En savoir plus
2013