2007
2007
Monday 03 December 2007
An alternative pathway for importing proteins into chloroplasts
Having identified the protein ceQORH as a novel chloroplast envelope protein, researchers at the Plant Cell Physiology Laboratory, jointly with a team from UJF Grenoble, have now revealed that this protein is imported into plastids by a system that is fully independent of the usual TOC pathway.
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An alternative pathway for importing proteins into chloroplasts
Having identified the protein ceQORH as a novel chloroplast envelope protein, researchers at the Plant Cell Physiology Laboratory, jointly with a team from UJF Grenoble, have now revealed that this protein is imported into plastids by a system that is fully independent of the usual TOC pathway.
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Monday 19 November 2007
Effects of cadmium on DNA repair
Under the Environmental Nuclear Toxicology programme, researchers from iRTSV, iBEB and DRFMC have revealed the differential effects of cadmium on DNA repair in vitro and in vivo in components of the murine immune system.
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Effects of cadmium on DNA repair
Under the Environmental Nuclear Toxicology programme, researchers from iRTSV, iBEB and DRFMC have revealed the differential effects of cadmium on DNA repair in vitro and in vivo in components of the murine immune system.
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Monday 19 November 2007
Biosynthesis of iron-sulphur clusters in chloroplasts
Using complementary approaches, the Biocatalysis team at theLaboratory of Metals in Chemistry and Biology and the team directed by M. Pilon (Fort Collins, USA) have characterized two novel SufE proteins (SufE2 and SufE3) in Arabidopsis thaliana chloroplasts.
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Biosynthesis of iron-sulphur clusters in chloroplasts
Using complementary approaches, the Biocatalysis team at theLaboratory of Metals in Chemistry and Biology and the team directed by M. Pilon (Fort Collins, USA) have characterized two novel SufE proteins (SufE2 and SufE3) in Arabidopsis thaliana chloroplasts.
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Monday 19 November 2007
Drosophila: a model for the study of bacterial virulence
A team from the Signal Transduction laboratory has eveloped in vivo models to discover or study factors of bacterial virulence, concerning Pseudomonas aeruginosa bacteria in particular.
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Drosophila: a model for the study of bacterial virulence
A team from the Signal Transduction laboratory has eveloped in vivo models to discover or study factors of bacterial virulence, concerning Pseudomonas aeruginosa bacteria in particular.
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Monday 19 November 2007
An iron-sulfphur protein essential for respiratory metabolism in Escherichia coli
The Biocatalysis team at the Laboratory of Metals in Chemistry and Biology partnered by the Bacterial Microbiology team at the CNRS unit in Marseille have jointly identified ErpA, a novel iron-sulphur protein that plays a key role in the Fe-S cluster assembly process.
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An iron-sulfphur protein essential for respiratory metabolism in Escherichia coli
The Biocatalysis team at the Laboratory of Metals in Chemistry and Biology partnered by the Bacterial Microbiology team at the CNRS unit in Marseille have jointly identified ErpA, a novel iron-sulphur protein that plays a key role in the Fe-S cluster assembly process.
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Monday 19 November 2007
Protecting against oxidative stress: understanding the active site of superoxide reductase
The group supervised by Vincent Nivière at the Laboratory of Metals in Chemistry and Biology has revealed an essential function of the active-site cysteine in superoxide reductase (SOR) that provides a key step in the elimination of radical superoxide O2•-.
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Protecting against oxidative stress: understanding the active site of superoxide reductase
The group supervised by Vincent Nivière at the Laboratory of Metals in Chemistry and Biology has revealed an essential function of the active-site cysteine in superoxide reductase (SOR) that provides a key step in the elimination of radical superoxide O2•-.
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Wednesday 10 October 2007
Rational design of peptide inhibitors of protein kinase CK2 subunit interaction
By demonstrating the in vitro reversibility of the CK2 multimeric structure, researchers at the Signal Transduction Laboratory can now define small peptide inhibitors that aid rational synthesis of chemical molecules capable of blocking this interaction.
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Rational design of peptide inhibitors of protein kinase CK2 subunit interaction
By demonstrating the in vitro reversibility of the CK2 multimeric structure, researchers at the Signal Transduction Laboratory can now define small peptide inhibitors that aid rational synthesis of chemical molecules capable of blocking this interaction.
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Friday 28 September 2007
Fe-S cluster metabolism as a target for Cobalt
The findings of the Biocatalysis team at the Laboratory of Metals in Chemistry and Biology support the hypothesis that cobalt inhibits the biosynthesis and/or repair of Fe-S clusters by competing directly with iron, and illustrate the importance of iron-sulphur cluster biogenesis in cells.
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Fe-S cluster metabolism as a target for Cobalt
The findings of the Biocatalysis team at the Laboratory of Metals in Chemistry and Biology support the hypothesis that cobalt inhibits the biosynthesis and/or repair of Fe-S clusters by competing directly with iron, and illustrate the importance of iron-sulphur cluster biogenesis in cells.
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Thursday 20 September 2007
Working towards a better understanding of the laws governing internal cell structure
The Biochip Laboratory develops new strategies for research into the laws governing internal cell structure.
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Working towards a better understanding of the laws governing internal cell structure
The Biochip Laboratory develops new strategies for research into the laws governing internal cell structure.
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Monday 04 June 2007
Folding and degradation of human IRP-1 is dependent on the subcellular environment
A team at the Laboratory of Metals in Chemistry and Biology, working alongside other researchers, has published findings on a human cytosolic aconitase protein showing that folding and degradation defects in proteins is strongly dependent on the subcellular environment.
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Folding and degradation of human IRP-1 is dependent on the subcellular environment
A team at the Laboratory of Metals in Chemistry and Biology, working alongside other researchers, has published findings on a human cytosolic aconitase protein showing that folding and degradation defects in proteins is strongly dependent on the subcellular environment.
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Monday 04 June 2007
Actin filament stochastic dynamics
For the first time, a team at the Plant Cell Physiology Laboratory has succeeded in reconstituting and visualising actin filament stochastic dynamics.
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Actin filament stochastic dynamics
For the first time, a team at the Plant Cell Physiology Laboratory has succeeded in reconstituting and visualising actin filament stochastic dynamics.
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Monday 04 June 2007
How do pathogenic bacteria control how their injection system is assembled?
A team of the Laboratory of Integrated Systems Biophysics and Biochemistry Research, in collaboration with the Membrane Proteins Laboratory (IBS), has uncovered the mechanism that controls how the toxin injection machinery of pathogenic bacteria is assembled.
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How do pathogenic bacteria control how their injection system is assembled?
A team of the Laboratory of Integrated Systems Biophysics and Biochemistry Research, in collaboration with the Membrane Proteins Laboratory (IBS), has uncovered the mechanism that controls how the toxin injection machinery of pathogenic bacteria is assembled.
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Monday 04 June 2007
IQGAP1 and VEGF control the migration of neural progenitor cells in adults
The Transduction Signal Laboratory and two others laboratories at the iRTSV and a research group at the University of Harvard (USA), has demonstrated for the first time the key role played by the protein IQGAP1 in the regulation of adult neurogenesis.
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IQGAP1 and VEGF control the migration of neural progenitor cells in adults
The Transduction Signal Laboratory and two others laboratories at the iRTSV and a research group at the University of Harvard (USA), has demonstrated for the first time the key role played by the protein IQGAP1 in the regulation of adult neurogenesis.
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Monday 02 April 2007
Biohydrogen: electrocatalytic hydrogen production using vitamin B12 models
Researchers at the Laboratory of Metals in Chemical and Biology seeking alternative solutions to the use of platinum in hydrogen production have shown that cobaloxime [Co(dmgBF2)2(OH2)2] (dmgH2 = dimethylglyoxime) is an effective catalyst for proton reduction in organic media with a low activation potential; they have suggested a unified mechanistic scheme involving metal-hydride derivatives.
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Biohydrogen: electrocatalytic hydrogen production using vitamin B12 models
Researchers at the Laboratory of Metals in Chemical and Biology seeking alternative solutions to the use of platinum in hydrogen production have shown that cobaloxime [Co(dmgBF2)2(OH2)2] (dmgH2 = dimethylglyoxime) is an effective catalyst for proton reduction in organic media with a low activation potential; they have suggested a unified mechanistic scheme involving metal-hydride derivatives.
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Monday 02 April 2007
A small site for a very large protein
To gain further insight into how AHNAK functions at a molecular and cellular scale, researchers at the Signal Transduction Laboratory searched for its interaction partners and identified the annexin 2/S100A10 complex.
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A small site for a very large protein
To gain further insight into how AHNAK functions at a molecular and cellular scale, researchers at the Signal Transduction Laboratory searched for its interaction partners and identified the annexin 2/S100A10 complex.
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Monday 02 April 2007
X-ray crystallography determination of the metal atom valence of protein active sites
A team at the Laboratory of Metals in Biological and Chemical, working with crystallographers from Caltech and Göttingen university finally broke the deadlock and identified the atoms involved in redox reactions, a breakthrough they achieved using crystallographic X-ray diffraction at several wavelengths close to the absorption threshold of the metals studied.
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X-ray crystallography determination of the metal atom valence of protein active sites
A team at the Laboratory of Metals in Biological and Chemical, working with crystallographers from Caltech and Göttingen university finally broke the deadlock and identified the atoms involved in redox reactions, a breakthrough they achieved using crystallographic X-ray diffraction at several wavelengths close to the absorption threshold of the metals studied.
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Monday 02 April 2007
Cancer stem cells and glioblastomas
Researchers at the Signal Transduction Laboratory have suggested that the role of multipotent stem cells and progenitors in the etiology of solid peripheral tumours is an idea that can be expanded to include solid tumours of the central nervous system.
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Cancer stem cells and glioblastomas
Researchers at the Signal Transduction Laboratory have suggested that the role of multipotent stem cells and progenitors in the etiology of solid peripheral tumours is an idea that can be expanded to include solid tumours of the central nervous system.
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Monday 02 April 2007
A proteomic dissection of Arabidopsis thaliana vacuoles isolated from cell culture
To better understand the mechanisms governing cellular traffic, storage of various metabolites and their ultimate degradation, Arabidopsis thaliana vacuoles proteomes were established. To this aim, a procedure was developed to prepare highly purified vacuoles from protoplasts isolated from Arabidopsis cell cultures using Ficoll density gradients.
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A proteomic dissection of Arabidopsis thaliana vacuoles isolated from cell culture
To better understand the mechanisms governing cellular traffic, storage of various metabolites and their ultimate degradation, Arabidopsis thaliana vacuoles proteomes were established. To this aim, a procedure was developed to prepare highly purified vacuoles from protoplasts isolated from Arabidopsis cell cultures using Ficoll density gradients.
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Monday 02 April 2007
Chlorophyll synthesis. Characterization of an enzyme that plays a key role in the development of photosynthetic cells
A joint team from the Plant Cell Physiology Laboratory (iRTSV) and the Plant Genome and Development Laboratory at Perpignan University has shown that Mg protoporphyrin IX methyltransferase plays a key role in chlorophyll synthesis and chloroplast development.
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Chlorophyll synthesis. Characterization of an enzyme that plays a key role in the development of photosynthetic cells
A joint team from the Plant Cell Physiology Laboratory (iRTSV) and the Plant Genome and Development Laboratory at Perpignan University has shown that Mg protoporphyrin IX methyltransferase plays a key role in chlorophyll synthesis and chloroplast development.
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Thursday 01 February 2007
The anticancer role of parthenolide: why?
It was through screening a collection of natural substances that the bioactive molecule screening centre (CMBA) working with Pierre Fabre laboratories and the IBiTec-S (CEA Saclay) high-throughput screening and combinatorial chemistry research group first discovered the potential of parthenolide as a promising new multifunctional anticancer drug.
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The anticancer role of parthenolide: why?
It was through screening a collection of natural substances that the bioactive molecule screening centre (CMBA) working with Pierre Fabre laboratories and the IBiTec-S (CEA Saclay) high-throughput screening and combinatorial chemistry research group first discovered the potential of parthenolide as a promising new multifunctional anticancer drug.
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Thursday 01 February 2007
DSIR: A new in silico method for predicting siRNA efficacy
The Laboratory of Biology, Informatics and Mathematics has teamed up with bioinformatics researchers at the Ecole des Mînes in Paris to devise a new method for predicting siRNA efficacy. DSIR (Designer of Small Interfering Rna).
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DSIR: A new in silico method for predicting siRNA efficacy
The Laboratory of Biology, Informatics and Mathematics has teamed up with bioinformatics researchers at the Ecole des Mînes in Paris to devise a new method for predicting siRNA efficacy. DSIR (Designer of Small Interfering Rna).
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Thursday 01 February 2007
Protein kinase CK2: a diagnostic/prognostic marker used in prostate cancer research
Researchers at the Signal Transduction Laboratory have shown that the status of protein kinase CK2 could become a determinative factor in the treatment of prostate cancer in humans.
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Protein kinase CK2: a diagnostic/prognostic marker used in prostate cancer research
Researchers at the Signal Transduction Laboratory have shown that the status of protein kinase CK2 could become a determinative factor in the treatment of prostate cancer in humans.
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Thursday 01 February 2007
Methionine catabolism in plants
A team at the Plant Cell Physiology Laboratory has been researching the methionine degradation pathway in Arabidopsis plants.
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Methionine catabolism in plants
A team at the Plant Cell Physiology Laboratory has been researching the methionine degradation pathway in Arabidopsis plants.
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2007