2012
2012
CEA
Wednesday 12 December 2012
Transfer and distribution of uranium in plants
Researchers from the Plant Cell & Physiology Laboratory are studying the impact of heavy metals on plant physiology and metabolism. They identified three possible scenarios of mobilization and accumulation of uranium in plants of agronomic interest grown in hydroponic conditions (soilless). Thus, rapeseed represents a promising species for phytoremediation strategies by phytoextraction, as rapeseed is capable of accumulating and transferring the greatest amount of uranium in its above ground tissues.
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Transfer and distribution of uranium in plants
Researchers from the Plant Cell & Physiology Laboratory are studying the impact of heavy metals on plant physiology and metabolism. They identified three possible scenarios of mobilization and accumulation of uranium in plants of agronomic interest grown in hydroponic conditions (soilless). Thus, rapeseed represents a promising species for phytoremediation strategies by phytoextraction, as rapeseed is capable of accumulating and transferring the greatest amount of uranium in its above ground tissues.
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CEA
Wednesday 12 December 2012
Bacterial diversity and biodegradation of pollutants
Researchers at the laboratory of Chemistry and Biology of Metals have studied soil bacteria that play a major role in the in situ biodegradation of polycyclic aromatic hydrocarbons. To identify such bacteria, they implemented molecular methods, involving a culture-independent strategy.
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Bacterial diversity and biodegradation of pollutants
Researchers at the laboratory of Chemistry and Biology of Metals have studied soil bacteria that play a major role in the in situ biodegradation of polycyclic aromatic hydrocarbons. To identify such bacteria, they implemented molecular methods, involving a culture-independent strategy.
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CEA
Wednesday 12 December 2012
Plant hormone and cadmium toxicity
Researchers from the Plant Cell & Physiology Laboratory aim to identify the mechanisms of tolerance and detoxification developed by plants to fight the pollution by cadmium. They showed a great similarity between gene regulation in response to the metal and in response to a plant hormone often compared to the human steroid hormones. Any addition of this hormone increases the toxicity of cadmium in the plant while its depletion increases tolerance to metal stress.
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Plant hormone and cadmium toxicity
Researchers from the Plant Cell & Physiology Laboratory aim to identify the mechanisms of tolerance and detoxification developed by plants to fight the pollution by cadmium. They showed a great similarity between gene regulation in response to the metal and in response to a plant hormone often compared to the human steroid hormones. Any addition of this hormone increases the toxicity of cadmium in the plant while its depletion increases tolerance to metal stress.
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CEA
Wednesday 12 December 2012
Prion protein and placental development
The study carried out by two teams of the Chemistry and Biology of Metals Laboratory and of the Cancer Biology and Infection laboratory demonstrates for the first time the physiological role of the prion protein in placental development. Deregulation of its expression is associated with the development of pathologies of pregnancy and affect the main angiogenic processes necessary for the establishment of the maternal-fetal circulation and to the growth of the placenta.
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Prion protein and placental development
The study carried out by two teams of the Chemistry and Biology of Metals Laboratory and of the Cancer Biology and Infection laboratory demonstrates for the first time the physiological role of the prion protein in placental development. Deregulation of its expression is associated with the development of pathologies of pregnancy and affect the main angiogenic processes necessary for the establishment of the maternal-fetal circulation and to the growth of the placenta.
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Wednesday 12 December 2012
A software named DSIR
siRNAs represent a powerful investigative tool for functional genomic studies and therapeutic evaluation. To date, the DSIR website, created by researchers at the Large Scale Biology laboratory, in collaboration with the Ecole des Mines Paris, offers a comprehensive service to design siRNA. In the new version, DSIR makes available a list of siRNA tested against 10 genes of interest in cancer and may also benefit designers of predictive models.
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A software named DSIR
siRNAs represent a powerful investigative tool for functional genomic studies and therapeutic evaluation. To date, the DSIR website, created by researchers at the Large Scale Biology laboratory, in collaboration with the Ecole des Mines Paris, offers a comprehensive service to design siRNA. In the new version, DSIR makes available a list of siRNA tested against 10 genes of interest in cancer and may also benefit designers of predictive models.
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Friday 05 October 2012
The order of acquisition of genetic alterations affect the tumor phenotype
Researchers from the laboratory of Cancer Biology and Infection performed the first functional demonstration that adrenocortical tumorigenesis responds to the principle of tumor progression by accumulation of genetic alterations and that the order of acquisition of these changes has a direct effect on the developed pathology.
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The order of acquisition of genetic alterations affect the tumor phenotype
Researchers from the laboratory of Cancer Biology and Infection performed the first functional demonstration that adrenocortical tumorigenesis responds to the principle of tumor progression by accumulation of genetic alterations and that the order of acquisition of these changes has a direct effect on the developed pathology.
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CEA
Friday 05 October 2012
BMP9 and BMP10, two new factors involved in angiogenesis
Researchers from the Laboratory of Cancer Biology and Infection confirm the in vivo role of BMP9 in postnatal angiogenesis and show for the first time the auxiliary role played by BMP10 in this process. BMP9 and 10 are the physiological ligands for ALK1 receptor whose absence causes severe defects in angiogenesis.
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BMP9 and BMP10, two new factors involved in angiogenesis
Researchers from the Laboratory of Cancer Biology and Infection confirm the in vivo role of BMP9 in postnatal angiogenesis and show for the first time the auxiliary role played by BMP10 in this process. BMP9 and 10 are the physiological ligands for ALK1 receptor whose absence causes severe defects in angiogenesis.
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Friday 05 October 2012
A link between amyloid fiber formation and apoptosis
Highlighting the involvement of a certain class of proteins in amyloid deposits characteristic of neurodegenerative diseases could represent one of the locks to understand the development of these diseases.
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A link between amyloid fiber formation and apoptosis
Highlighting the involvement of a certain class of proteins in amyloid deposits characteristic of neurodegenerative diseases could represent one of the locks to understand the development of these diseases.
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Friday 05 October 2012
Methylation and chloroplastic metabolism
New data suggest that the chloroplast carbon metabolism could be regulated by methylation. This finding opens important perspectives on the role of methylation of certain chloroplast proteins (Rubisco and / or aldolase) on crop yield and production of molecules with high added value by chloroplasts.
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Methylation and chloroplastic metabolism
New data suggest that the chloroplast carbon metabolism could be regulated by methylation. This finding opens important perspectives on the role of methylation of certain chloroplast proteins (Rubisco and / or aldolase) on crop yield and production of molecules with high added value by chloroplasts.
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Friday 05 October 2012
A new herbicide and pesticide molecule
A new antiparasitic target representing a new structure in the range of active molecules directed against apicomplexan (vectors of malaria and toxoplasmosis) has been highlighted by researchers of the Plant Cell & Physiology Laboratory and of the high throughput screening platform of the institute.
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A new herbicide and pesticide molecule
A new antiparasitic target representing a new structure in the range of active molecules directed against apicomplexan (vectors of malaria and toxoplasmosis) has been highlighted by researchers of the Plant Cell & Physiology Laboratory and of the high throughput screening platform of the institute.
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CEA
Tuesday 04 September 2012
PredAlgo - A new subcellular localization prediction tool dedicated to green algae
To improve production yields of 3rd generation biofuels, biologists seek to domesticate the process of conversion and storage of solar energy from microalgae. Studies focus in particular on the chloroplast, an organelle where photosynthesis takes place and at the origin of the production of energetic reserves (starch or lipids). In the ALGOMICS project, researchers at the large Scale Biology Laboratory in collaboration with others from the iBEB have developed a tool to annotate protein from the model alga Chlamydomonas reinhardtii, in order to track their location in different cellular compartments (including chloroplast).
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PredAlgo - A new subcellular localization prediction tool dedicated to green algae
To improve production yields of 3rd generation biofuels, biologists seek to domesticate the process of conversion and storage of solar energy from microalgae. Studies focus in particular on the chloroplast, an organelle where photosynthesis takes place and at the origin of the production of energetic reserves (starch or lipids). In the ALGOMICS project, researchers at the large Scale Biology Laboratory in collaboration with others from the iBEB have developed a tool to annotate protein from the model alga Chlamydomonas reinhardtii, in order to track their location in different cellular compartments (including chloroplast).
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Wednesday 01 August 2012
The wind rose of epidermal cells fate
The skin, the first physical and immune barrier of the organism with the environment is in constant renewal. A laboratory team of the BGE laboratory has identified the key molecular mechanisms that regulate the proliferation and death of keratinocytes, the main cells of the epidermis.
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The wind rose of epidermal cells fate
The skin, the first physical and immune barrier of the organism with the environment is in constant renewal. A laboratory team of the BGE laboratory has identified the key molecular mechanisms that regulate the proliferation and death of keratinocytes, the main cells of the epidermis.
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CEA
Wednesday 01 August 2012
Mechanistic study of the biosynthesis of NAD. Toward a new anti-bacterial agent?
Bacterial resistance to antibiotics encourages researchers to find new antibacterial substances and new targets. Chemistry and Biology of Metals laboratory biologists found how to prevent in vivo multiplication of Escherichia coli by targeting a novel enzyme involved in a key pathway, specific to bacteria. This discovery is a challenge since none inhibitor for the incriminated enzyme, the quinolinate synthase (NadA), have been reported to date. This inhibitor is being tested on Mycobacterium leprae and Helicobacter pylori.
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Mechanistic study of the biosynthesis of NAD. Toward a new anti-bacterial agent?
Bacterial resistance to antibiotics encourages researchers to find new antibacterial substances and new targets. Chemistry and Biology of Metals laboratory biologists found how to prevent in vivo multiplication of Escherichia coli by targeting a novel enzyme involved in a key pathway, specific to bacteria. This discovery is a challenge since none inhibitor for the incriminated enzyme, the quinolinate synthase (NadA), have been reported to date. This inhibitor is being tested on Mycobacterium leprae and Helicobacter pylori.
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Wednesday 01 August 2012
New clinical application of soluble VE-cadherin: Rheumatoid arthritis
Rheumatoid arthritis is a very commonn autoimmune disease, characterized by an exacerbated inflammatory response at the joints and by increased cardiovascular risk. Rheumatologists do not yet have a predictive marker to prevent atherosclerosis associated with this pathology. The BCI Laboratory researchers have shown that the blood test VE-cadherin (a protein that ensures the cohesion of endothelial cells of blood vessel walls) is a promising candidate.
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New clinical application of soluble VE-cadherin: Rheumatoid arthritis
Rheumatoid arthritis is a very commonn autoimmune disease, characterized by an exacerbated inflammatory response at the joints and by increased cardiovascular risk. Rheumatologists do not yet have a predictive marker to prevent atherosclerosis associated with this pathology. The BCI Laboratory researchers have shown that the blood test VE-cadherin (a protein that ensures the cohesion of endothelial cells of blood vessel walls) is a promising candidate.
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Thursday 07 June 2012
Mimic the living to study the mechanisms of cell contraction
Thanks to the design of a device mimicking cell skeleton or cytoskeleton (1), researchers from CEA CNRS and Université Joseph Fourier (2) were able to decrypt for the first time part of the laws of organization defining the architecture of the cells. These researchers have shown that motor molecules, myosins, were responsible for the selective contraction of certain intracellular structures formed by actin, a protein abundantly present in the cells. The highlighted mechanism allows to understand how the generation of forces within cells can be locally modulated in a very accurately manner. Such results open new perspectives, especially for the understanding of dysfunctions observed in some pathologies such as cancer. This work was published online June 07, in the journal Science.
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Mimic the living to study the mechanisms of cell contraction
Thanks to the design of a device mimicking cell skeleton or cytoskeleton (1), researchers from CEA CNRS and Université Joseph Fourier (2) were able to decrypt for the first time part of the laws of organization defining the architecture of the cells. These researchers have shown that motor molecules, myosins, were responsible for the selective contraction of certain intracellular structures formed by actin, a protein abundantly present in the cells. The highlighted mechanism allows to understand how the generation of forces within cells can be locally modulated in a very accurately manner. Such results open new perspectives, especially for the understanding of dysfunctions observed in some pathologies such as cancer. This work was published online June 07, in the journal Science.
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Tuesday 22 May 2012
Shellfish ...
A team from the Large Scale Biology laboratory has developed Toxint'patch, a transportable electronic device for the detection of toxins. Toxint'patch is intended for applications such as control of the bathing water, agro-food, bio-defense, etc..
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Shellfish ...
A team from the Large Scale Biology laboratory has developed Toxint'patch, a transportable electronic device for the detection of toxins. Toxint'patch is intended for applications such as control of the bathing water, agro-food, bio-defense, etc..
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CEA
Tuesday 22 May 2012
Hyperforin, a plant extract having antidepressant properties and influencing zinc homeostasis
Researchers at the Chemistry and Biology of Metals Laboratory are working on hyperforin, a bioactive molecule isolated from a plant and exhibiting antidepressant effects. The other pharmacological interests of hyperforin reside in the fact that it is a potent inhibitor of angiogenesis and it displays anti-inflammatory properties.
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Hyperforin, a plant extract having antidepressant properties and influencing zinc homeostasis
Researchers at the Chemistry and Biology of Metals Laboratory are working on hyperforin, a bioactive molecule isolated from a plant and exhibiting antidepressant effects. The other pharmacological interests of hyperforin reside in the fact that it is a potent inhibitor of angiogenesis and it displays anti-inflammatory properties.
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Thursday 26 April 2012
Demonstration of a "channeling"mechanism in the biosynthetic pathway of vitamin B8 in plants
In collaboration with IBS, researchers at the Plant Cell & Physiology Laboratory have biochemically characterized the bifunctional enzyme BIO3-BIO1 from Arabidopsis and solved its three-dimensional structure. Data concerning bifunctional enzyme catalyzing (or not) two successive stages of the same biosynthetic pathway are rare. This study is therefore essential from a fundamental point of view, but will also improve the production processes of molecules with high added value. This will also, in a more targeted way, enable the design of specific inhibitors aimed at therapeutic or pesticide spurposes.
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Demonstration of a "channeling"mechanism in the biosynthetic pathway of vitamin B8 in plants
In collaboration with IBS, researchers at the Plant Cell & Physiology Laboratory have biochemically characterized the bifunctional enzyme BIO3-BIO1 from Arabidopsis and solved its three-dimensional structure. Data concerning bifunctional enzyme catalyzing (or not) two successive stages of the same biosynthetic pathway are rare. This study is therefore essential from a fundamental point of view, but will also improve the production processes of molecules with high added value. This will also, in a more targeted way, enable the design of specific inhibitors aimed at therapeutic or pesticide spurposes.
En savoir plus
Thursday 26 April 2012
What's new on the injectisome side- a target for new anti-bacterial?
The results of the researchers at the Biology of Cancer and Infection laboratory allow progress in understanding the role of eukaryotic cells in the control of the injection of toxins of the pathogenic bacterium Pseudomonas aeruginosa and allow to consider some strategies of inhibition regarding this system virulence.
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What's new on the injectisome side- a target for new anti-bacterial?
The results of the researchers at the Biology of Cancer and Infection laboratory allow progress in understanding the role of eukaryotic cells in the control of the injection of toxins of the pathogenic bacterium Pseudomonas aeruginosa and allow to consider some strategies of inhibition regarding this system virulence.
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CEA
Thursday 26 April 2012
Bevacizumab as a treatment of the Rendu-Osler disease
A preliminary study of 25 patients suggested that bevacizumab could be a new therapeutic option in the treatment of Rendu-Osler disease for patients awaiting liver transplantation.
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Bevacizumab as a treatment of the Rendu-Osler disease
A preliminary study of 25 patients suggested that bevacizumab could be a new therapeutic option in the treatment of Rendu-Osler disease for patients awaiting liver transplantation.
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CEA
Thursday 26 April 2012
An plant organelle found in parasites responsible for malaria and toxoplasmosis inspire new treatments
Review published in Chemical Reviews.
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An plant organelle found in parasites responsible for malaria and toxoplasmosis inspire new treatments
Review published in Chemical Reviews.
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CEA
Monday 12 March 2012
EGEVE
EGEVE is a clinical trial in search of an early biological marker of preeclampsia.
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EGEVE
EGEVE is a clinical trial in search of an early biological marker of preeclampsia.
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Monday 12 March 2012
Eat for food or defend themselves? from phagocytosis to cellular cannibalism
Review published in Trends in Molecular Medicine.
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Eat for food or defend themselves? from phagocytosis to cellular cannibalism
Review published in Trends in Molecular Medicine.
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Tuesday 06 March 2012
Updated mechanical laws within multicellular architectures
Malfunctions of morphogenetic processes are responsible for the proper functioning of the organs. They contribute to the formation of tumors and their evolution in metastases. Using a minimal system, researchers at the Plant Cell & Physiology Laboratory are strating to formulate morphogenetic laws.
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Updated mechanical laws within multicellular architectures
Malfunctions of morphogenetic processes are responsible for the proper functioning of the organs. They contribute to the formation of tumors and their evolution in metastases. Using a minimal system, researchers at the Plant Cell & Physiology Laboratory are strating to formulate morphogenetic laws.
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Tuesday 06 March 2012
A dogma falls
Biology of Cancer and Infection laboratory researchers elucidate how molecular players involved in cell to cell interactions interact and demonstrate that the understanding we had so far is wrong.
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A dogma falls
Biology of Cancer and Infection laboratory researchers elucidate how molecular players involved in cell to cell interactions interact and demonstrate that the understanding we had so far is wrong.
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Tuesday 06 March 2012
Deubiquitinase and selective autophagy
Data published by researchers at theLarge Scale Biology laboratory show that the inactivation of a deubiquitinase (enzyme eliminating ubiquitin residues) is sufficient to cause the accumulation of ubiquinylated protein aggregates and open new avenues for understanding the origin of proteinopathies (Huntington disease, Alzheimer's ...). That works describe for the first time the involvement of deubiquitinase in the selective control of ubiquinylated autophagy substrates in Drosophila and also in models of human cells in culture.
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Deubiquitinase and selective autophagy
Data published by researchers at theLarge Scale Biology laboratory show that the inactivation of a deubiquitinase (enzyme eliminating ubiquitin residues) is sufficient to cause the accumulation of ubiquinylated protein aggregates and open new avenues for understanding the origin of proteinopathies (Huntington disease, Alzheimer's ...). That works describe for the first time the involvement of deubiquitinase in the selective control of ubiquinylated autophagy substrates in Drosophila and also in models of human cells in culture.
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CEA
Monday 05 March 2012
The deprotonation-induced valence inversion is a concerted mechanism
The work undertaken in this study was aimed at deciphering the mechanism of an electron transfer associated to a proton transfer within a dinuclear iron complex. The results obtained allow to propose that in the observed reaction the transfers of the electron and proton are concerted.
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The deprotonation-induced valence inversion is a concerted mechanism
The work undertaken in this study was aimed at deciphering the mechanism of an electron transfer associated to a proton transfer within a dinuclear iron complex. The results obtained allow to propose that in the observed reaction the transfers of the electron and proton are concerted.
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CEA
Thursday 26 January 2012
First biochemical characterization of a Cu+-ATPase from plant
After producing sufficient and active form for one of the three P-type ATPases of the membrane wicha llows for copper transport in the chloroplast, researchers at the Plant Cell & Physiology laboratory and at the Chemistry and Biology of Metals laboratory performed the first biochemical characterization of this ATPase. This study was made possible by the bacterium Lactobacillus lactis and will provide key informations about the relative roles of P-type ATPases in metal homeostasis of the chloroplast.
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First biochemical characterization of a Cu+-ATPase from plant
After producing sufficient and active form for one of the three P-type ATPases of the membrane wicha llows for copper transport in the chloroplast, researchers at the Plant Cell & Physiology laboratory and at the Chemistry and Biology of Metals laboratory performed the first biochemical characterization of this ATPase. This study was made possible by the bacterium Lactobacillus lactis and will provide key informations about the relative roles of P-type ATPases in metal homeostasis of the chloroplast.
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CEA
Thursday 26 January 2012
Reactional mechanism of HPPD: Identification of catalytic residues
Despite the phytosanitary (molecular target of herbicides) and pharmaceutical interests (HPPD inhibitors are used as therapeutic agents and are undergoing clinical trials in the treatment of Parkinson's disease), the reaction mechanism of 4-hydroxyphenylpyruvate dioxygenase (HPPD) has not yet been fully elucidated. Researchers at the Plant Cell & Physiology laboratory and at the Chemistry and Biology of Metals laboratory determined the role of catalytic residues that may interact with the substrate and with the reaction intermediates of HPPD.
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Reactional mechanism of HPPD: Identification of catalytic residues
Despite the phytosanitary (molecular target of herbicides) and pharmaceutical interests (HPPD inhibitors are used as therapeutic agents and are undergoing clinical trials in the treatment of Parkinson's disease), the reaction mechanism of 4-hydroxyphenylpyruvate dioxygenase (HPPD) has not yet been fully elucidated. Researchers at the Plant Cell & Physiology laboratory and at the Chemistry and Biology of Metals laboratory determined the role of catalytic residues that may interact with the substrate and with the reaction intermediates of HPPD.
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CEA
Thursday 26 January 2012
Coenzyme Q with a vanilla flavor
The primary coenzyme Q deficiency causes severe pathologies in humans. In a recent study, Chemistry and Biology of Metals laboratory researchers showed that synthetic analogues of the precursor of the aromatic ring of Q, could also serve as precursors for the Q biosynthesis which opens new perspectives for human therapy.
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Coenzyme Q with a vanilla flavor
The primary coenzyme Q deficiency causes severe pathologies in humans. In a recent study, Chemistry and Biology of Metals laboratory researchers showed that synthetic analogues of the precursor of the aromatic ring of Q, could also serve as precursors for the Q biosynthesis which opens new perspectives for human therapy.
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CEA
Thursday 26 January 2012
New biomarkers of preeclampsia
Researchers from the Cancer Biology and Infection laboratory are interested in the study of soluble PCDH12 and of EG-VEGF witch may be involved in the development of preeclampsia, the largest pathology of pregnancy. Following recent results, they propose these two proteins as potential new markers for the occurrence of this disease.
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New biomarkers of preeclampsia
Researchers from the Cancer Biology and Infection laboratory are interested in the study of soluble PCDH12 and of EG-VEGF witch may be involved in the development of preeclampsia, the largest pathology of pregnancy. Following recent results, they propose these two proteins as potential new markers for the occurrence of this disease.
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CEA
Thursday 26 January 2012
PSAQ™-SRM: A method for the quantification of biomarkers
The PSAQ ™ method is dedicated to the quantification of protein biomarkers in body fluids. This method is based on mass spectrometry analysis of clinical samples and uses whole proteins, labeled with stable isotopes, as quantification standards. PSAQ allows a very accurate and precise quantification of disease biomarkers. In addition, PSAQ has unique capacities to simultaneously quantify several protein biomarkers in body fluids such as plasma.
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PSAQ™-SRM: A method for the quantification of biomarkers
The PSAQ ™ method is dedicated to the quantification of protein biomarkers in body fluids. This method is based on mass spectrometry analysis of clinical samples and uses whole proteins, labeled with stable isotopes, as quantification standards. PSAQ allows a very accurate and precise quantification of disease biomarkers. In addition, PSAQ has unique capacities to simultaneously quantify several protein biomarkers in body fluids such as plasma.
En savoir plus
Wednesday 25 January 2012
World first cell race
The first world race of cells emerged. Odile Filhol-Cochet, researcher at the Biology of Cancer and Infection laboratory received a silver medal by submitting a human mammary epithelial cell line.
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World first cell race
The first world race of cells emerged. Odile Filhol-Cochet, researcher at the Biology of Cancer and Infection laboratory received a silver medal by submitting a human mammary epithelial cell line.
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CEA
Wednesday 25 January 2012
Award
Delphine Ciais, a researcher at the Cancer Biology and Infection laboratory won the prize for the best poster at the 3rd Congress of the French Society of Angiogenesis.
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Award
Delphine Ciais, a researcher at the Cancer Biology and Infection laboratory won the prize for the best poster at the 3rd Congress of the French Society of Angiogenesis.
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2012