PhD theses
2011
Simon Arragain.
Biological radical sulfur insertion. A study of methylthiotransferases.
[Abstract] [Thesis on line]
Michaël Carboni.
A biomimetic approach to study Iron-Manganese enzymes.
[Abstract] [Thesis on line]
Sylvain Chauvet.
Gα12 and Gα13 in cystic fibrosis: Role in F508del-CFTR degradation and in the control of intercellular junctions.
[Abstract] [Thesis on line]
Julien Gibon.
Roles of TRPC6 channels and of the antidepressant hyperforin in the homeostasis of zinc in murine cortical neurons.
[Abstract] [Thesis on line]
Christophe Horwath.
Making and caracterisation of protein nano-devices.
[Abstract] [Thesis on line]
Florence Martin.
Bacterial diversity exploration in hydrocarbon polluted soil: metabolic potential and degrader community evolution revealed by isotope labeling.
[Abstract] [Thesis on line]
Delphine Salvatore.
Interactions at molecular scale and assembly mechanisms between two proteins : α-lactalbumine and lysozyme.
[Abstract] [Thesis on line]
2010
Pascal Guillo.
Development of new ruthenium based catalysts for oxydation reaction: Towards photocatalytic systems.
[Astract] [Thesis on line]
Frédéric Oddon.
Artificial oxygenases: New tools for the asymmetric oxidation catalysis of alkenes and thioethers in the context of the “green chemistry”.
[Abstract] [Thesis on line]
2009
Karthik Arumugam.
Structure prediction of P1-type ATPases and molecular dynamic simulation on their Metal Binding Domains.
[Abstract] [Thesis on line]
Florence Bonnot.
Superoxide reductase: Mechanism of electron transfer to the active site and the role of lysine 48 in catalysis.
[Abstract] [Thesis on line]
Sigolène Canaguier.
Modelling the active site of NiFe hydrogenases: New catalysts for the electro-production of H2 and mechanistic studies.
[Abstract] [Thesis on line]
Carine Rousset.
Structural and Functional studies of Quinolinate Synthase: An iron-sulfur protein as a key target of antibacterial agents.
[Abstract] [Thesis on line]
Émilie Tremey.
Role of the axial cysteine ligand in the iron active site of superoxide reductase.
[Abstract] [Thesis on line]
Peng Tu.
Study of diacylglycerol-activated TRPC6 channels in cortical neurons and their roles in the transport of transition metals.
[Abstract] [Thesis on line]
Sylvia Vitale.
Anti-Fur inhibitors and Fur from Helicobacter pylori.
[Abstract] [Thesis on line]
2008
Clément Blanchet.
Protein refolding and amyloid fiber formation: A case study with α-lactalbumin.
[Abstract] [Thesis on line]
Alexia Chandor-Proust.
Study of Spore Photoproduct Lyase, a “Radical-SAM” enzyme involved in DNA repair.
[Abstract] [Thesis on line]
Éric Gouré.
Amine transfer reactions catalyzed by binuclear non heme iron systems: High oxidation state intermediates.
[Abstract] [Thesis on line]
Simon Gudin.
Study of the copper ATPase Ccc2 of Saccharomyces cerevisiae. From localization to function.
[Abstract] [Thesis on line]
Julien Micoud.
Interdomains interactions roles in CFTR protein.
[Abstract] [Thesis on line]
Élodie Nicolau.
Biodegradation of 2-ethylhexyl nitrate by Mycobacterium austroafricanum IFP 2173.
[Abstract] [Thesis on line]
Daouda Traore.
Structural studies of the PerR protein: A metalloprotein sensor of H2O2.
[Abstract] [Thesis on line]
2007
Béatrice De Keukeleire.
Identification of a novel degradation pathway GTP dependent in the endoplasmic reticulum: Exemple of the mutated protein F508del-CFTR.
[Abstract] [Thesis on line]
Abdelnasser El Ghazouani.
Biochemical and functional characterizations of the PerR protein (Bacillus subtilis): A bacterial sensor of hydrogen peroxide.
[Abstract] [Thesis on line]
Caroline Fauquant.
Metal and DNA binding properties of NikR from Escherichia coli and of NikR and FUR from Helicobacter pylori.
[Abstract] [Thesis on line]
Aurélie Gardarin.
Cadmium, ATPase-P, levure : du transport à la toxicité.
[Abstract]
Caroline Montagner.
Study of the insertion of the translocation domain of botulinum toxin within the membranes: A biophysical approach.
[Abstract] [Thesis on line]
Estelle Rousselet.
Cellular response to cadmium exposure in animals.
[Abstract] [Thesis on line]
Maïté Sendra.
Mechanistic studies of the biosynthesis of iron sulfur clusters in Escherichia coli: Which role for the SufA protein?
[Abstract] [Thesis on line]
2006
Nicolas Duraffourg.
Détermination de la structure par RMN d'une protéine impliquée dans la biosynthèse des centres Fe-S : SufA.
[Abstract] [Thesis on line]
Camille Dycke.
Modulation of the activity of Iron Regulatory Proteins by various mechanisms.
[Abstract]
Florence Luttringer.
The anaerobic ribonucleotide reductase from Escherichia coli, a zinc protein. Importance of the metal-binding site for the enzyme structure and activation.
[Abstract] [Thesis on line]
Yohan Oudart.
Modèles structuraux et fonctionnel du site actif des hydrogénases [NiFe] : de nouveaux catalyseurs bio-inspirés pour la production d'hydrogène.
[Abstract] [Thesis on line]
Grégory Vernier.
Conformational diversity and versatility of proteins/lipids interactions. A case study of α-lactalbumine and apomyoglobin.
[Abstract] [Thesis on line]
2005
Nadia Abed.
The Fur protein, a new antibacterial target ? Approach using petide aptamers..
[Abstract]
Fabienne Gally.
Étude structure/fonction d'une proteine ABC : SUR, le récepteur des sulfonylurées.
[Abstract] [Thesis on line]
Christelle Mathé.
Études structure-fonction des superoxydes réductases. Mise en évidence de nouvelles espèces intermédiaires au niveau du site actif.
[Abstract]
Isabelle Morin.
Inquiry into copper delivery to the secretory pathway in yeast. Role of the metallo-chaperonne Atx1 and the copper ATPase Ccc2.
[Abstract]
Ludovic Pecqueur.
Role of the zinc and the cysteines in the dimerization of the Ferric Uptake Regulator (FUR) from E. coli: a structural approach using NMR.
[Abstract] [Thesis on line]
David Poger.
Structure, dynamique moléculaire et sélectivité de métallochaperones à cuivre et à mercure.
[Abstract] [Thesis on line]
Julien Valton.
Aromatic hydroxylation reaction catalyzed by a two-component flavin-dependent hydroxylase: The ActVA-ActVB sytem from Streptomyces coelicolor.
[Abstract]
Sébastien Weisbuch.
Study of initial kinetic events of apomyoglobin folding.
[Abstract] [Thesis on line]
Chen-Chou Wu.
Identification et caractérisation des sites de transport de CadA, l'ATPase-cadmium de Listeria monocytogenes.
[Abstract] [Thesis on line]
2004
Natalia Bouchmarina.
Étude du mécanisme du repliement des protéines par les méthodes biophysiques sur deux protéines modèles : l'α lactalbumine et l'anhydrase carbonique B.
[Abstract]
Fabien Pierrel.
Modification des ARNt par une protéine «Radical-SAM». Étude de la protéine MiaB.
[Abstract]
Emmanuel Rossy.
Uptake and traffick of inorganic mercury in Ralstonia metallidurans CH34.
[Abstract]
Sébastien Schoumacker.
Oxydation énantiosélective de sulfures, par l'eau oxygénée catalysée par des complexes de fer (+II), de fer (+III) ou de manganèse (+II), et par des N-alkyloxaziridines activables par des acides de Lewis.
[Abstract]
Philippe Simon.
Nouveaux outils pour la coupure et la détection d'ADN.
[Abstract]
Charlotte Vendrely.
Mécanismes d'assemblade de la protéine prion de souris.
[Abstract]
2003
Frédéric Avenier.
Étude mécanistique des réactions de transfert d'oxygène et d'amine catalysées par des complexes dinucléaires de fer : biomimétisme et catalyse.
[Abstract]
Ingrid Bourges.
Characterization of the assembly pathway of human mitochondrial complex I.
[Abstract]
Anne-Lise Prost.
Physiological and pharmacological regulation of SUR, the regulatory subunit of the ATP-sensitive potassium channel, and functional homologies with the other ABC proteins of the MRP subtype.
[Abstract]
Laurent Filisetti.
Flavine réductases et réactions d'hydroxylation - étude enzymatique d'ActVB de Streptomyces coelicolor.
[Abstract]
Ludovic Champier.
Characterization of regulatory proteins involved in the inorganic mercury resistance in Ralstonia metallidurans CH34.
[Abstract]
2002
Benoît d’Autréaux.
Spectroscopic studies of the Fur protein (Ferric Uptake regulation). Interaction with nitric oxide.
[Abstract]
Nathalie Bal.
Functional study of CadA, the cadmium ATPase from Listeria monocytogenes.
[Abstract]
Réjane Beugnot.
Étude fonctionnelle et génétique du complexe I mitochondrial humain à travers l'analyse de cas pathologiques.
Hélène Jacquet-Bouix.
Molecular pharmacology of an ABC transporter: sulfonylurea receptor, KATP channel subunit.
[Abstract]
Jennifer Lowe.
Caractérisation des domaines transmembranaires essentiels au transport du cuivre par l'ATPase-cuivre de Saccharomyces cerevisiae.
[Abstract]
Christophe Moreau.
Molecular basis of the mechanism of action of the potassium channel openers on KATP channels.
[Abstract]
Dominique Padovani.
Centres FeS et catalyse rédox. Activation de la ribonucléase réductase anaérobie en protéine radicalaire.
[Abstract]
François Verge.
Nouvelles potentialités des complexes dinucléaires de fer (III) à pont µ-oxo : vers des nucléases artificielles.
[Abstract]
Murielle Roux.
Contribution to the study of the reduction of selenite by Ralstonia metallidurans CH34.
[Abstract]
2001
Lionel Dubois.
Synthèse et étude de complexes biomimétiques du site actif des catalases à manganèse : étude mécanistique de la réaction de dismutation du peroxyde d'hydrogène.
[Abstract]
Cécile Dueymes.
Synthesis of flavin- or deazaflavin-oligonucleotide conjugates. Study of hybridization with RNA or DNA complementary sequences and enzymatic reduction.
[Abstract]
Murielle Lombard.
Superoxyde Reductase Activity: Evidence for a new enzymatic activity involved in the fight against superoxide stress.
[Abstract]
Yasmina Mekmouche.
Oxydations d'alcanes et de sulfures par des hydroperoxydes catalysées par des complexes de fer : vers une chimie contrôlée par le métal.
[Abstract]
2000
Anne Gonzalez de Peredo.
Étude structurale de al protéine FUR (Ferric Uptake Regulation) d’Escherichia coli par spectrométrie de masse.
Alexandra Breheret.
Design of catalysts for the alkane oxydation by peroxides.
[Abstract]