Scientific results
CEA
Wednesday 05 November 2008
De nouvelles avancées pour deux maladies génétiques : Huntington et l’ataxie cérebelleuse de type 3 (SCA3)
Enjeu : Mise au point de thérapies innovantes
De nouvelles avancées pour deux maladies génétiques : Huntington et l’ataxie cérebelleuse de type 3 (SCA3)
Enjeu : Mise au point de thérapies innovantes
Neurol. (In Press)
CEA
Tuesday 04 November 2008
Imagerie multimodale (PET/fluorescence) de nano-objet
Enjeu : Mieux voir et mieux quantifier
Imagerie multimodale (PET/fluorescence) de nano-objet
Enjeu : Mieux voir et mieux quantifier
Bioconjug Chem. 19(9):1921-1926
CEA
Friday 17 October 2008
La spectroscopie RMN permet de sonder la compartimentation du métabolisme à l’échelle cellulaire
Enjeu : Mesurer le métabolisme énergétique in vivo à l’échelle cellulaire, échelle inaccessible par les techniques classiques d’imagerie
La spectroscopie RMN permet de sonder la compartimentation du métabolisme à l’échelle cellulaire
Enjeu : Mesurer le métabolisme énergétique in vivo à l’échelle cellulaire, échelle inaccessible par les techniques classiques d’imagerie
Magn Reson Med 60(2):306-311
CEA
Wednesday 24 September 2008
Schizophrénie de l’adolescent : mise en évidence d'anomalies anatomiques du cerveau
Les chercheurs de l’unité mixte CEA-Inserm du SHFJ (U797 - Neuroimagerie & Psychiatrie) en partenariat avec l’Institut de Psychiatrie de Londres (IoP) viennent de montrer que le cortex du lobe temporal du cerveau d‘adolescents atteints de schizophrénie présente des anomalies anatomiques. L’étude a porté sur une cinquantaine d’adolescents âgés de 16 ans en moyenne. Ces résultats font l’objet d’une publication dans le numéro d’octobre du Journal of the American Academy of Child and Adolescent Psychiatry.
Schizophrénie de l’adolescent : mise en évidence d'anomalies anatomiques du cerveau
Les chercheurs de l’unité mixte CEA-Inserm du SHFJ (U797 - Neuroimagerie & Psychiatrie) en partenariat avec l’Institut de Psychiatrie de Londres (IoP) viennent de montrer que le cortex du lobe temporal du cerveau d‘adolescents atteints de schizophrénie présente des anomalies anatomiques. L’étude a porté sur une cinquantaine d’adolescents âgés de 16 ans en moyenne. Ces résultats font l’objet d’une publication dans le numéro d’octobre du Journal of the American Academy of Child and Adolescent Psychiatry.
Journal of the American Academy of Child and Adolescent Psychiatry. 47:10, Oct. 2008
CEA
Thursday 31 July 2008
Comment l’EPO protège des neurones soumis à un stress ischémique
Enjeu : Nouvelles stratégies thérapeutiques
Comment l’EPO protège des neurones soumis à un stress ischémique
Enjeu : Nouvelles stratégies thérapeutiques
Proc Natl Acad Sci U S A. 2008
CEA
Wednesday 30 July 2008
Publication d’un ouvrage par le Docteur E. D. Carsosella (SRHI) : « l’identité changeante de l’individu »
Enjeu : Comprendre l’identité de l’individu
Publication d’un ouvrage par le Docteur E. D. Carsosella (SRHI) : « l’identité changeante de l’individu »
Enjeu : Comprendre l’identité de l’individu
L'identité changeante de l'individu. Ed. L'Harmattan
CEA
Wednesday 16 July 2008
HLA-G nous éclaire sur la pré-éclampsie
Enjeu : Amélioration du diagnostic et du pronostic de pathologies de la grossesse
HLA-G nous éclaire sur la pré-éclampsie
Enjeu : Amélioration du diagnostic et du pronostic de pathologies de la grossesse
Biology of Reproduction, 2008
CEA
Wednesday 16 July 2008
A l’origine des asymétries structurelles de notre cerveau…
Enjeu : Comprendre le développement cérébral chez le nourrisson sain
A l’origine des asymétries structurelles de notre cerveau…
Enjeu : Comprendre le développement cérébral chez le nourrisson sain
Cereb Cortex 2008
CEA
Monday 09 June 2008
Intuitions of number-space in Amazonian indigenous groups
Can you calculate without having a numeral system? To answer this question, since 2002 a team of CEA, CNRS and Inserm researchers coordinated by the head of the joint Inserm-CEA-run Cognitive Neuroimaging research unit, Stanislas Dehaene, has focused on the Mundurucu people, an Amazonian indigenous people who live in small villages isolated from western-world influence and who possess only a limited numerical lexicon. Drawing on methods developed in cognitive psychology, the team has recently revealed that the Mundurucu people possess an intuitive sense of number-space relations, although their sense of measurement [1] is learning-acquired. These results, which were published in the 30 May issue of Science, determine how mathematical mapping is split between cultural invention and intuition. Most significantly, these results underline the importance of adapting the methods for learning in this field.
Intuitions of number-space in Amazonian indigenous groups
Can you calculate without having a numeral system? To answer this question, since 2002 a team of CEA, CNRS and Inserm researchers coordinated by the head of the joint Inserm-CEA-run Cognitive Neuroimaging research unit, Stanislas Dehaene, has focused on the Mundurucu people, an Amazonian indigenous people who live in small villages isolated from western-world influence and who possess only a limited numerical lexicon. Drawing on methods developed in cognitive psychology, the team has recently revealed that the Mundurucu people possess an intuitive sense of number-space relations, although their sense of measurement [1] is learning-acquired. These results, which were published in the 30 May issue of Science, determine how mathematical mapping is split between cultural invention and intuition. Most significantly, these results underline the importance of adapting the methods for learning in this field.
Science. In press
CEA
Wednesday 14 May 2008
Du nouveau dans le traitement des données informatiques en IRM fonctionnelle
Enjeux : Accéder à la variabilité régionale de la dynamique cérébrale tout en localisant les activations cérébrales
Du nouveau dans le traitement des données informatiques en IRM fonctionnelle
Enjeux : Accéder à la variabilité régionale de la dynamique cérébrale tout en localisant les activations cérébrales
NeuroImage. In press.
CEA
Friday 18 April 2008
Huntington’s Disease: role of dopamine in the regulation of neuron metabolism
to develop new therapeutic treatments for neurological diseases
Huntington’s Disease: role of dopamine in the regulation of neuron metabolism
to develop new therapeutic treatments for neurological diseases
Hum Mol Genet. In press
CEA
Friday 18 April 2008
First-episode mania* : first or second-generation anti-psychotics ?**
To assess whether second-generation ant-psychotics are superior to first-generation anti-psychotics in terms of efficacy and tolerance: economic and public health issues
First-episode mania* : first or second-generation anti-psychotics ?**
To assess whether second-generation ant-psychotics are superior to first-generation anti-psychotics in terms of efficacy and tolerance: economic and public health issues
Lancet. 371:1085-1097
CEA
Thursday 10 April 2008
Precision measurements of brain activity by MRI, at 200 ms and in 3D: it can be done!
Faster MRI image acquisition
Precision measurements of brain activity by MRI, at 200 ms and in 3D: it can be done!
Faster MRI image acquisition
J Magn Reson Imaging. 27(4):744-53
CEA
Tuesday 18 March 2008
Definition of the tolerability properties of mesenchymal stem cells*
Challenges: Anti-graft-rejection cell therapy in bone marrow and solid organ transplantation
Definition of the tolerability properties of mesenchymal stem cells*
Challenges: Anti-graft-rejection cell therapy in bone marrow and solid organ transplantation
Stem Cells 2008, 26:212-222.
CEA
Tuesday 18 March 2008
Parkinson's disease: steps toward new potential treatments using gene therapy
Teams from MIRCen, working in partnership with Oxford Biomedica, Paris 12 university and Paris Mondor Hospital, are launching Europe’s first* set of clinical gene therapy trials on Parkinson’s disease.
Parkinson's disease: steps toward new potential treatments using gene therapy
Teams from MIRCen, working in partnership with Oxford Biomedica, Paris 12 university and Paris Mondor Hospital, are launching Europe’s first* set of clinical gene therapy trials on Parkinson’s disease.
CEA
Thursday 07 February 2008
Instant diagnosis using diffusion MRI
Real-time observation of the anatomical connectivity of the brain
Instant diagnosis using diffusion MRI
Real-time observation of the anatomical connectivity of the brain
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. (2007) 10: 27-35.
CEA
Thursday 03 January 2008
3-month-old infants possess number sense
All humans, regardless of their culture and education, possess what we call number sense. It is through number sense that we can, for example, perceive the rough number of objects in a set within a fraction of a second. Over the last twenty years or so, methods employed in behavioural research have shown how 5 to 6-month-old infants possess number sense. A team from the cognitive neuroimaging laboratory at NeuroSpin(1) (joint CEA-Inserm Unit 562) have been the first to highlight brain regions activated in number processing in 3-month-old infants. The results of this study, which was led at Kremlin-Bicêtre Hospital in Paris, were published in the February 5 2008 release of PloS Biology. (1) NeuroSpin is attached to the CEA's Institute of Biomedical Imaging, I²BM
3-month-old infants possess number sense
All humans, regardless of their culture and education, possess what we call number sense. It is through number sense that we can, for example, perceive the rough number of objects in a set within a fraction of a second. Over the last twenty years or so, methods employed in behavioural research have shown how 5 to 6-month-old infants possess number sense. A team from the cognitive neuroimaging laboratory at NeuroSpin(1) (joint CEA-Inserm Unit 562) have been the first to highlight brain regions activated in number processing in 3-month-old infants. The results of this study, which was led at Kremlin-Bicêtre Hospital in Paris, were published in the February 5 2008 release of PloS Biology. (1) NeuroSpin is attached to the CEA's Institute of Biomedical Imaging, I²BM
"Distinct Cerebral Pathways for Object identity and Number in Human Infants”, Izard V, Dehaene-Lambertz G, Dehaene S (2008). Plos Biology (6):2 e11