Life Sciences Division

PhD theses

Cheickna Cissé.
Structural study of anti-FUR peptide aptamers and their interactions with their target.
[Abstract] [On-line thesis]

Simon Arragain.
Biological radical sulfur insertion. A study of methylthiotransferases.
[Abstract] [On-line thesis]

Michaël Carboni.
A biomimetic approach to study Iron-Manganese enzymes.
[Abstract] [On-line thesis]

Sylvain Chauvet.
Gα₁₂ and Gα₁₃ in cystic fibrosis: Role in F508del-CFTR degradation and in the control of intercellular junctions.
[Abstract] [On-line thesis]

Julien Gibon.
Roles of TRPC6 channels and of the antidepressant hyperforin in the homeostasis of zinc in murine cortical neurons.
[Abstract] [On-line thesis]

Christophe Horwath.
Making and caracterisation of protein nano-devices.
[Abstract] [On-line thesis]

Florence Martin.
Bacterial diversity exploration in hydrocarbon polluted soil: metabolic potential and degrader community evolution revealed by isotope labeling.
[Abstract] [On-line thesis]

Delphine Salvatore.
Interactions at molecular scale and assembly mechanisms between two proteins : α-lactalbumine and lysozyme.
[Abstract] [On-line thesis]

Pascal Guillo.
Development of new ruthenium based catalysts for oxydation reaction: Towards photocatalytic systems.
[Astract] [On-line thesis]

Frédéric Oddon.
Artificial oxygenases: New tools for the asymmetric oxidation catalysis of alkenes and thioethers in the context of the “green chemistry”.
[Abstract] [On-line thesis]

Karthik Arumugam.
Structure prediction of P1-type ATPases and molecular dynamic simulation on their Metal Binding Domains.
[Abstract] [On-line thesis]

Florence Bonnot.
Superoxide reductase: Mechanism of electron transfer to the active site and the role of lysine 48 in catalysis.
[Abstract] [On-line thesis]

Sigolène Canaguier.
Modelling the active site of NiFe hydrogenases: New catalysts for the electro-production of H₂ and mechanistic studies.
[Abstract] [On-line thesis]

Carine Rousset.
Structural and Functional studies of Quinolinate Synthase: An iron-sulfur protein as a key target of antibacterial agents.
[Abstract] [On-line thesis]

Émilie Tremey.
Role of the axial cysteine ligand in the iron active site of superoxide reductase.
[Abstract] [On-line thesis]

Peng Tu.
Study of diacylglycerol-activated TRPC6 channels in cortical neurons and their roles in the transport of transition metals.
[Abstract] [On-line thesis]

Sylvia Vitale.
Anti-Fur inhibitors and Fur from Helicobacter pylori.
[Abstract] [On-line thesis]

Clément Blanchet.
Protein refolding and amyloid fiber formation: A case study with α-lactalbumin.
[Abstract] [On-line thesis]

Alexia Chandor-Proust.
Study of Spore Photoproduct Lyase, a “Radical-SAM” enzyme involved in DNA repair.
[Abstract] [On-line thesis]

Éric Gouré.
Amine transfer reactions catalyzed by binuclear non heme iron systems: High oxidation state intermediates.
[Abstract] [On-line thesis]

Simon Gudin.
Study of the copper ATPase Ccc2 of Saccharomyces cerevisiae. From localization to function.
[Abstract] [On-line thesis]

Julien Micoud.
Interdomains interactions roles in CFTR protein.
[Abstract] [On-line thesis]

Élodie Nicolau.
Biodegradation of 2-ethylhexyl nitrate by Mycobacterium austroafricanum IFP 2173.
[Abstract] [On-line thesis]

Daouda Traore.
Structural studies of the PerR protein: A metalloprotein sensor of H₂O₂.
[Abstract] [On-line thesis]

Béatrice De Keukeleire.
Identification of a novel degradation pathway GTP dependent in the endoplasmic reticulum: Exemple of the mutated protein F508del-CFTR.
[Abstract] [On-line thesis]

Abdelnasser El Ghazouani.
Biochemical and functional characterizations of the PerR protein (Bacillus subtilis): A bacterial sensor of hydrogen peroxide.
[Abstract] [On-line thesis]

Caroline Fauquant.
Metal and DNA binding properties of NikR from Escherichia coli and of NikR and FUR from Helicobacter pylori.
[Abstract] [On-line thesis]

Aurélie Gardarin.
Cadmium, ATPase-P, levure : du transport à la toxicité.
[Abstract]

Caroline Montagner.
Study of the insertion of the translocation domain of botulinum toxin within the membranes: A biophysical approach.
[Abstract] [On-line thesis]

Estelle Rousselet.
Cellular response to cadmium exposure in animals.
[Abstract] [On-line thesis]

Maïté Sendra.
Mechanistic studies of the biosynthesis of iron sulfur clusters in Escherichia coli: Which role for the SufA protein?
[Abstract] [On-line thesis]

Nicolas Duraffourg.
Détermination de la structure par RMN d'une protéine impliquée dans la biosynthèse des centres Fe-S : SufA.
[Abstract] [On-line thesis]

Camille Dycke.
Modulation of the activity of Iron Regulatory Proteins by various mechanisms.
[Abstract]

Florence Luttringer.
The anaerobic ribonucleotide reductase from Escherichia coli, a zinc protein. Importance of the metal-binding site for the enzyme structure and activation.
[Abstract] [On-line thesis]

Yohan Oudart.
Modèles structuraux et fonctionnel du site actif des hydrogénases [NiFe] : de nouveaux catalyseurs bio-inspirés pour la production d'hydrogène.
[Abstract] [On-line thesis]

Grégory Vernier.
Conformational diversity and versatility of proteins/lipids interactions. A case study of α-lactalbumine and apomyoglobin.
[Abstract] [On-line thesis]

Nadia Abed.
The Fur protein, a new antibacterial target ? Approach using petide aptamers..
[Abstract]

Fabienne Gally.
Étude structure/fonction d'une proteine ABC : SUR, le récepteur des sulfonylurées.
[Abstract] [On-line thesis]

Christelle Mathé.
Études structure-fonction des superoxydes réductases. Mise en évidence de nouvelles espèces intermédiaires au niveau du site actif.
[Abstract]

Isabelle Morin.
Inquiry into copper delivery to the secretory pathway in yeast. Role of the metallo-chaperonne Atx1 and the copper ATPase Ccc2.
[Abstract]

Ludovic Pecqueur.
Role of the zinc and the cysteines in the dimerization of the Ferric Uptake Regulator (FUR) from E. coli: a structural approach using NMR.
[Abstract] [On-line thesis]

David Poger.
Structure, dynamique moléculaire et sélectivité de métallochaperones à cuivre et à mercure.
[Abstract] [On-line thesis]

Julien Valton.
Aromatic hydroxylation reaction catalyzed by a two-component flavin-dependent hydroxylase: The ActVA-ActVB sytem from Streptomyces coelicolor.
[Abstract]

Sébastien Weisbuch.
Study of initial kinetic events of apomyoglobin folding.
[Abstract] [On-line thesis]

Chen-Chou Wu.
Identification et caractérisation des sites de transport de CadA, l'ATPase-cadmium de Listeria monocytogenes.
[Abstract] [On-line thesis]

Natalia Bouchmarina.
Étude du mécanisme du repliement des protéines par les méthodes biophysiques sur deux protéines modèles : l'α lactalbumine et l'anhydrase carbonique B.
[Abstract]

Fabien Pierrel.
Modification des ARNt par une protéine «Radical-SAM». Étude de la protéine MiaB.
[Abstract]

Emmanuel Rossy.
Uptake and traffick of inorganic mercury in Ralstonia metallidurans CH34.
[Abstract]

Sébastien Schoumacker.
Oxydation énantiosélective de sulfures, par l'eau oxygénée catalysée par des complexes de fer (+II), de fer (+III) ou de manganèse (+II), et par des N-alkyloxaziridines activables par des acides de Lewis.
[Abstract]

Philippe Simon.
Nouveaux outils pour la coupure et la détection d'ADN.
[Abstract]

Charlotte Vendrely.
Mécanismes d'assemblade de la protéine prion de souris.
[Abstract]

Frédéric Avenier.
Étude mécanistique des réactions de transfert d'oxygène et d'amine catalysées par des complexes dinucléaires de fer : biomimétisme et catalyse.
[Abstract]

Ingrid Bourges.
Characterization of the assembly pathway of human mitochondrial complex I.
[Abstract]

Anne-Lise Prost.
Physiological and pharmacological regulation of SUR, the regulatory subunit of the ATP-sensitive potassium channel, and functional homologies with the other ABC proteins of the MRP subtype.
[Abstract]

Laurent Filisetti.
Flavine réductases et réactions d'hydroxylation - étude enzymatique d'ActVB de Streptomyces coelicolor.
[Abstract]

Ludovic Champier.
Characterization of regulatory proteins involved in the inorganic mercury resistance in Ralstonia metallidurans CH34.
[Abstract]

Benoît d’Autréaux.
Spectroscopic studies of the Fur protein (Ferric Uptake regulation). Interaction with nitric oxide.
[Abstract]

Nathalie Bal.
Functional study of CadA, the cadmium ATPase from Listeria monocytogenes.
[Abstract]

Réjane Beugnot.
Étude fonctionnelle et génétique du complexe I mitochondrial humain à travers l'analyse de cas pathologiques.

Hélène Jacquet-Bouix.
Molecular pharmacology of an ABC transporter: sulfonylurea receptor, K_ATP channel subunit.
[Abstract]

Jennifer Lowe.
Caractérisation des domaines transmembranaires essentiels au transport du cuivre par l'ATPase-cuivre de Saccharomyces cerevisiae.
[Abstract]

Christophe Moreau.
Molecular basis of the mechanism of action of the potassium channel openers on K_ATP channels.
[Abstract]

Dominique Padovani.
Centres FeS et catalyse rédox. Activation de la ribonucléase réductase anaérobie en protéine radicalaire.
[Abstract]

François Verge.
Nouvelles potentialités des complexes dinucléaires de fer (III) à pont µ-oxo : vers des nucléases artificielles.
[Abstract]

Murielle Roux.
Contribution to the study of the reduction of selenite by Ralstonia metallidurans CH34.
[Abstract]

Lionel Dubois.
Synthèse et étude de complexes biomimétiques du site actif des catalases à manganèse : étude mécanistique de la réaction de dismutation du peroxyde d'hydrogène.
[Abstract]

Cécile Dueymes.
Synthesis of flavin- or deazaflavin-oligonucleotide conjugates. Study of hybridization with RNA or DNA complementary sequences and enzymatic reduction.
[Abstract]

Murielle Lombard.
Superoxyde Reductase Activity: Evidence for a new enzymatic activity involved in the fight against superoxide stress.
[Abstract]

Yasmina Mekmouche.
Oxydations d'alcanes et de sulfures par des hydroperoxydes catalysées par des complexes de fer : vers une chimie contrôlée par le métal.
[Abstract]

Anne Gonzalez de Peredo.
Étude structurale de al protéine FUR (Ferric Uptake Regulation) d’Escherichia coli par spectrométrie de masse.

Alexandra Breheret.
Design of catalysts for the alkane oxydation by peroxides.
[Abstract]