Scientific results
CEA
Tuesday 23 April 2013
Theranexus: boosting the effectiveness of psychotropics
CEA The start-up Theranexus, a spin-off from the CEA, was launched on March 19. Its objective: to propose an adjuvant treatment [1] to be given in addition to psychotropic [2] medications that will augment their effectiveness or, in diminished doses, reduce their undesirable effects. Theranexus will be engaged in a large part of the product chain, from preclinical research to phase 2 clinical trials.
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Theranexus: boosting the effectiveness of psychotropics
CEA The start-up Theranexus, a spin-off from the CEA, was launched on March 19. Its objective: to propose an adjuvant treatment [1] to be given in addition to psychotropic [2] medications that will augment their effectiveness or, in diminished doses, reduce their undesirable effects. Theranexus will be engaged in a large part of the product chain, from preclinical research to phase 2 clinical trials.
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© L Simonneau/Inserm
Tuesday 02 April 2013
Producing new neurons under all circumstances: just a mouse away…
Improving neuron production in elderly persons presenting with a decline in cognition is a major challenge facing an ageing society and the emergence of neuro-degenerative conditions such as Alzheimer’s disease. INSERM and CEA researchers recently showed that the pharmacological blocking of the TGFβ molecule improves the production of new neurons in the mouse model. These results incentivise the development of targeted therapies enabling improved neuron production to alleviate cognitive decline in the elderly and reduce cerebral lesions caused by radiotherapy. The research is published in the journal EMBO Molecular Medicine.
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Producing new neurons under all circumstances: just a mouse away…
Improving neuron production in elderly persons presenting with a decline in cognition is a major challenge facing an ageing society and the emergence of neuro-degenerative conditions such as Alzheimer’s disease. INSERM and CEA researchers recently showed that the pharmacological blocking of the TGFβ molecule improves the production of new neurons in the mouse model. These results incentivise the development of targeted therapies enabling improved neuron production to alleviate cognitive decline in the elderly and reduce cerebral lesions caused by radiotherapy. The research is published in the journal EMBO Molecular Medicine.
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CEA
Friday 22 March 2013
Quantum dot: a promising new imaging agent
The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI [1], has developed a new surface chemistry for these particularly effective nanoparticles.
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Quantum dot: a promising new imaging agent
The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI [1], has developed a new surface chemistry for these particularly effective nanoparticles.
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G. Lesénéchal/CEA
Friday 15 March 2013
Research agreement with Canada: production of microalgae while decontaminating industrial sites
French Prime Minister Jean-Marc Ayrault announced March 14 in Ottawa, with his Canadian counterpart Stephen Harper, the signature of an agreement for a collaboration between the CEA’s Department of Life Sciences and Canada’s National Research Council (NRC). This partnership aims to explore the potential in using gas and industrial wastes for the production of microalgae (3rd generation biofuels).
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Research agreement with Canada: production of microalgae while decontaminating industrial sites
French Prime Minister Jean-Marc Ayrault announced March 14 in Ottawa, with his Canadian counterpart Stephen Harper, the signature of an agreement for a collaboration between the CEA’s Department of Life Sciences and Canada’s National Research Council (NRC). This partnership aims to explore the potential in using gas and industrial wastes for the production of microalgae (3rd generation biofuels).
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CEA
Thursday 28 February 2013
Living fuel cells
Bacteria contain astonishing enzymes that could inspire scientists in the fabrication of fuel cells. Such is the case for researchers from the IBS, who have just determined the crystallographic structure and mechanism of action for an enzyme from Escherichia coli.
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Living fuel cells
Bacteria contain astonishing enzymes that could inspire scientists in the fabrication of fuel cells. Such is the case for researchers from the IBS, who have just determined the crystallographic structure and mechanism of action for an enzyme from Escherichia coli.
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CEA
Tuesday 26 February 2013
By the sixth month of pregnancy,the human brain is capable of processing speech
The immature brain of a premature infant is capable, at the age of three months pre-term, of distinguishing syllables uttered by male and female voices. These results obtained by INSERM researchers at the University of Picardy Jules Verne and the CEA’s NeuroSpin Imaging Centre, were published in the PNAS journal dated 25 February 2013. They highlight the very early sophisticated organisation of the regions of the brain involved in language-processing and social communication in humans.
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By the sixth month of pregnancy,the human brain is capable of processing speech
The immature brain of a premature infant is capable, at the age of three months pre-term, of distinguishing syllables uttered by male and female voices. These results obtained by INSERM researchers at the University of Picardy Jules Verne and the CEA’s NeuroSpin Imaging Centre, were published in the PNAS journal dated 25 February 2013. They highlight the very early sophisticated organisation of the regions of the brain involved in language-processing and social communication in humans.
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CEA
Monday 25 February 2013
Lynch Syndrome: structural biology in the service of diagnostic support
Researchers at the CEA, CNRS and Université Paris-Sud have presented the first model of the architecture of the MLH1 protein associated with Lynch syndrome, a genetic predisposition to colorectal cancer. This atomic level “image” of MLH1 will lead to better understanding of the genetic processes that cause the disease. This result is the starting point of a clinical diagnostic support project with La Timone University Hospital (Marseille public hospital system) and Institut Curie (Paris) to target treatments based on numerous variants of this anomaly.
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Lynch Syndrome: structural biology in the service of diagnostic support
Researchers at the CEA, CNRS and Université Paris-Sud have presented the first model of the architecture of the MLH1 protein associated with Lynch syndrome, a genetic predisposition to colorectal cancer. This atomic level “image” of MLH1 will lead to better understanding of the genetic processes that cause the disease. This result is the starting point of a clinical diagnostic support project with La Timone University Hospital (Marseille public hospital system) and Institut Curie (Paris) to target treatments based on numerous variants of this anomaly.
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Piscine d'entreposage de combustibles nucléaires ©L.Godart/CEA
Tuesday 12 February 2013
The discovery of microalgae with an exceptional radiotolerance
A new, highly radiotolerant microalga species has just been isolated from a cooling pool for spent nuclear fuel. After analyzing the properties of this unique species, researchers now foresee new strategies for bioremediation [1].
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The discovery of microalgae with an exceptional radiotolerance
A new, highly radiotolerant microalga species has just been isolated from a cooling pool for spent nuclear fuel. After analyzing the properties of this unique species, researchers now foresee new strategies for bioremediation [1].
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CEA
Monday 11 February 2013
Using biological connections for microelectronics
The miniaturization of electronic components is now reaching its physical limitations. Even if space can be saved by using a three-dimensional assembly solution, manufacturing electrical connections for these new devices is still a technological challenge. A team of biologists and physicists has now devised a system of self-assembled connections, thanks to actin filaments [1].
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Using biological connections for microelectronics
The miniaturization of electronic components is now reaching its physical limitations. Even if space can be saved by using a three-dimensional assembly solution, manufacturing electrical connections for these new devices is still a technological challenge. A team of biologists and physicists has now devised a system of self-assembled connections, thanks to actin filaments [1].
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EPFL
Tuesday 29 January 2013
The Human Brain Project wins Top European Science Funding
Federating more than 80 European and international research institutions, the Human Brain Project was selected by the European Commission as one of its two FET Flagship projects on January 28th.
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The Human Brain Project wins Top European Science Funding
Federating more than 80 European and international research institutions, the Human Brain Project was selected by the European Commission as one of its two FET Flagship projects on January 28th.
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CEA
Monday 21 January 2013
Creation of the “Integrated Structural Biology, Grenoble (ISBG)” mixed research institute
The Unité Mixte de Service (mixed research institute) UMS 3518 (CNRS-CEA-UJF-EMBL) was created on January 1st 2013, in Grenoble. This new unit brings together facilities from the IBS and UVHCI, and represents an impressive collection of state-of-the-art equipment for integrated structural biology. The unit is open to national and international scientific communities, as well as industry.
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Creation of the “Integrated Structural Biology, Grenoble (ISBG)” mixed research institute
The Unité Mixte de Service (mixed research institute) UMS 3518 (CNRS-CEA-UJF-EMBL) was created on January 1st 2013, in Grenoble. This new unit brings together facilities from the IBS and UVHCI, and represents an impressive collection of state-of-the-art equipment for integrated structural biology. The unit is open to national and international scientific communities, as well as industry.
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Friday 18 January 2013
Experimental proof for the harmful effects of bisphenol A
A team from the CEA-iRCM has just experimentally demonstrated for the first time that low concentrations of bisphenol A are sufficient to have a negative impact on human testes.
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Experimental proof for the harmful effects of bisphenol A
A team from the CEA-iRCM has just experimentally demonstrated for the first time that low concentrations of bisphenol A are sufficient to have a negative impact on human testes.
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G. Lesénéchal/CEA
Tuesday 08 January 2013
Microphyt and the CEA have teamed up to exploit the potential of photosynthetic microalgae
The company Microphyt is outsourcing part of its R&D to the CEA, as part of an agreement over four years to develop the BOLERO program. The focus of this program is on improving mass production procedures, and the development of molecules of interest that are synthesized by the green microalgae of the genus Chlamydomonas.
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Microphyt and the CEA have teamed up to exploit the potential of photosynthetic microalgae
The company Microphyt is outsourcing part of its R&D to the CEA, as part of an agreement over four years to develop the BOLERO program. The focus of this program is on improving mass production procedures, and the development of molecules of interest that are synthesized by the green microalgae of the genus Chlamydomonas.
En savoir plus
Institut Pasteur
Monday 07 January 2013
Retracing the evolutionary history and emergence of tuberculosis
Scientists from the Pasteur Institutes in Paris and Lille, the CNRS, INRSERM and the Université Lille 2, in collaboration with the CEA-Genoscope and the Sanger Institute, have recently determined the origin of the emergence of the bacteria Mycobacterium tuberculosis, the primary causative agent of tuberculosis. The researchers also provide clues to the evolutionary success of this pathogen, including several genetic mechanisms that could have contributed to its global dispersal, which currently infects up to 2 billion people. This work, published January 6 on the website Nature Genetics, offers some valuable perspectives for identifying new targets in the fight against tuberculosis.
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Retracing the evolutionary history and emergence of tuberculosis
Scientists from the Pasteur Institutes in Paris and Lille, the CNRS, INRSERM and the Université Lille 2, in collaboration with the CEA-Genoscope and the Sanger Institute, have recently determined the origin of the emergence of the bacteria Mycobacterium tuberculosis, the primary causative agent of tuberculosis. The researchers also provide clues to the evolutionary success of this pathogen, including several genetic mechanisms that could have contributed to its global dispersal, which currently infects up to 2 billion people. This work, published January 6 on the website Nature Genetics, offers some valuable perspectives for identifying new targets in the fight against tuberculosis.
En savoir plus