Monday March 16 2009
CEA
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To know more, « Analyse automatisée des lésions de la matière blanche en IRM : suivi longitudinal d’une grande cohorte de sujets âgés » sur les pages de l'I²BM.
MRI and brain ageing
CEA
Researchers at the Centre for Imaging, Neuroscience and Disease Applications CI-NAPS (I²BM/Caen) have developed and validated an automatic algorithm for the detection, quantification, localisation and mapping of small lesions of the brain’s white matter (WMLs) in MR images.
Although these small lesions are visible to the naked eye on magnetic resonance (MR) images, this detection is difficult, tedious and has a low reproducibility. The method designed by the researchers allows individual monitoring of each lesion. It has been applied to the analysis of a cohort of 1200 subjects aged over 65 years as part of joint work with the INSERM Neuroepidemiology Unit. This approach offers a valuable tool to help explain the causes and the cognitive and motor consequences of WMLs in the elderly. It will allow early screening of at-risk subjects bearing numerous lesions, and the evaluation of the efficacy of new therapies for neurodegenerative disorders such as Alzheimer’s disease. The identification of the mechanisms of normal and pathological brain ageing is a major challenge for our ‘ageing’ society.
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To know more, « Analyse automatisée des lésions de la matière blanche en IRM : suivi longitudinal d’une grande cohorte de sujets âgés » sur les pages de l'I²BM.