Laboratoire d'imagerie moléculaire expérimentale - Principales publications
Kuhnast B, Hinnen F, Hamzavi R, Boisgard R, Tavitian B, Nielsen P, Dollé F. Fluorine-18 labelling of PNAs functionalized at their pseudo-peptidic backbone for imaging studies with PET. J. Label.Compounds Radiopharm; 48, 51–61.
Boisgard R, Kuhnast B, Vonhoff S, Younes C, Hinnen F, Verbavatz JM, Rousseau B, Fürste JP, Wlotzka B, Dollé F, Klussmann S, Tavitian B. In vivo biodistribution and pharmacokinetics of fluorine-18-labeled Spiegelmers: a new class of oligonucleotidic radiopharmaceuticals. Eur. J. Nucl. Med. Mol. Im. 32(4), 470-477.
Cerchia L*, Ducongé F*, Pestourie C, Boulay J, Aissouni Y, Gombert K, Tavitian B, de Franciscis V, Libri L (2005). Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase. PLoS Biology 3(4), e123. * co-first authors
De Bruin B, Kuhnast B, Hinnen F, Yaouancq L, Amessou M, Johannes L, Samson A, Boisgard R, Tavitian B, Dollé F (2005). 1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione : Design, Synthesis and Radiosynthesis of a New [18F]Fluoropyridine- Based Maleimide Reagent for the Labeling of Peptides and Proteins. BioConj. Chem. 16, 406-420.
Kuhnast B, de Bruin B, Hinnen F, Tavitian B, Dollé F (2004). Design and Synthesis of a New [18F]Fluoropyridine-Based Haloacetamide Reagent for the Labeling of Oligonucleotides: 2-Bromo-N-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]acetamide. BioConj. Chem. 15, 617-627.
Josserand V, Pèlerin H, de Bruin B, Jego B, Kuhnast B, Ducongé F, Ezan E, Dollé F, Mabondzo A, Tavitian B (2004). Evaluation de la pénétration cérébrale : une double étude utilisant un modèle in vitro de barrière hémato-encéphalique humaine et l'imagerie par tomographie d'émission de positons in vivo. Médecine Nucléaire 28(8), 392-6.
Boisgard, R., Vincent-Naulleau, S., Leplat, J.-J., Bouet, S., Le Chalony, C., Tricaud, Y., Horak, V., Geffrotin, C., Frelat,•G., and Tavitian, B. (2003). A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs. Eur. J. Nucl. Med. Mol. Im. 30, 826-834
Hamzavi R., Dollé F., Tavitian B., Dahl O., Nielsen P.E. (2003) Modulation of the Pharmacokinetic Properties of PNA: Preparation of galactosyl, mannosyl, fucosyl, N-acetyl-galactosaminyl and N-acetyl-glucosaminyl derivatives of aminoethylglycin peptide nucleic acid monomers and their incorporation into PNA oligomers. BioConj. Chem. 14(5), 941-54.
Tavitian, B., Marzabal, S., Boutet, V., Kuhnast, B., Terrazzino, S., Moynier, M., Dolle, F., Deverre, JR., & Thierry, A. R. (2002). Characterization of a synthetic anionic vector for oligonucleotide delivery using in vivo whole body dynamic imaging. Pharmaceut.Res. 19, 367-376.
Younes, C. K., Boisgard, R., & Tavitian, B. (2002). Labelled oligonucleotides as radiopharmaceuticals: pitfalls, problems and perspectives. Curr.Pharm.Des. 8, 1451-1466.
Blomqvist, G., Tavitian, B., Pappata, S., Crouzel, C., Jobert, A., Doignon, I., & Di Giamberardino, L. (2001). Quantitative measurement of cerebral acetylcholinesterase using [11C]physostigmine and positron emission tomography. J.Cereb.Blood Flow Metab. 21, 114-131.
Darfeuille, F., Cazenave, C., Gryaznov, S., Duconge, F., Di Primo, C., & Toulme, J. J. (2001). RNA and N3'-->P5' kissing aptamers targeted to the trans-activation responsive (TAR) RNA of the human immunodeficiency virus-1. Nucleosides Nucleotides Nucleic Acids 20, 441-449.
Kuhnast, B., Dolle, F., Terrazzino, S., Rousseau, B., Loc'h, C., Vaufrey, F., Hinnen, F., Doignon, I., Pillon, F., David, C., Crouzel, C., & Tavitian, B. (2000). General method to label antisense oligonucleotides with radioactive halogens for pharmacological and imaging studies. Bioconjug.Chem. 11, 627-636.
Kuhnast, B., Dolle, F., Vaufrey, F., Hinnen, F., Crouzel, C., & Tavitian, B. (2000). Fluorine-18 labeling of oligonucleotides bearing chemically – modified ribose – phosphate backbones. J.Labelled Compd.Rad. 43, 837-848.
Duconge, F. & Toulme, J. J. (1999). In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1. RNA. 5, 1605-1614.
Marzabal, S., Terrazzino, S., Kühnast, B., Dolle, F., Deverre, J. R., Jobert, A., Crouzel, C., Di Giamberardino, L., & Tavitian B. (1999). In vivo imaging and pharmacokinetics of oligonucleotides. Nucleos.Nucleot. 18, 1731-1733.
Traykov, L., Tavitian, B., Jobert, A., Boller, F., Forette, F., Crouzel, C., Di Giamberardino, L., & Pappata, S. (1999). In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects. Eur.J.Neurol. 6, 273-278.
Tavitian, B., Terrazzino, S., Kühnast, B., Marzabal, S., Stettler, O., Dolle, F., Deverre, J. R., Jobert, A., Hinnen, F., Bendriem, B., David, C., & di Giamberardino J. (1998). In vivo Imaging of Oligonucleotides with Positron Emission Tomography. Nature Medicine 4, 467-471.